Neuronal differentiation and expression of neural epitopes in pituitary adenomas

Mahlon Johnson, Xuemo Fan, Pat Bourne, Daniele Walters

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Neural transdifferentiation is increasingly recognized in neural crest and neural stem cell tumors. Neuronal differentiation has been anecdotally described primarily in somatotroph cell adenomas associated with acromegaly, but its prevalence in adenomas and relationship to adenoma type has not been completely established. In this study we performed a retrospective morphological and immunohistochemical analysis of neurofilament, phosphoneurofilament, Neu-N, class III tubulin, and Hu in WHO grade I pituitary adenomas. Limited numbers of cells with neuronal features and neuron-associated epitopes may be more common in pituitary adenomas than previously recognized. These may occur in many forms of adenomas including somatotroph, lactotroph, mixed somatotroph and lactotroph, null cell/gonadotroph cell and, rarely, corticotropin cell adenomas.

Original languageEnglish (US)
Pages (from-to)1265-1271
Number of pages7
JournalJournal of Histochemistry and Cytochemistry
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2007

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Pituitary Neoplasms
Growth Hormone-Secreting Pituitary Adenoma
Adenoma
Lactotrophs
Epitopes
Somatotrophs
Gonadotrophs
Null Lymphocytes
Acromegaly
Neural Stem Cells
Intermediate Filaments
Neural Crest
Tubulin
Adrenocorticotropic Hormone
Cell Count
Neurons
Neoplasms

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology

Cite this

Neuronal differentiation and expression of neural epitopes in pituitary adenomas. / Johnson, Mahlon; Fan, Xuemo; Bourne, Pat; Walters, Daniele.

In: Journal of Histochemistry and Cytochemistry, Vol. 55, No. 12, 01.12.2007, p. 1265-1271.

Research output: Contribution to journalArticle

Johnson, Mahlon ; Fan, Xuemo ; Bourne, Pat ; Walters, Daniele. / Neuronal differentiation and expression of neural epitopes in pituitary adenomas. In: Journal of Histochemistry and Cytochemistry. 2007 ; Vol. 55, No. 12. pp. 1265-1271.
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