Neuropharmacology of sleep and wakefulness

2012 update

Christopher J. Watson, Helen Baghdoyan, Ralph Lydic

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs, but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects, and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This article reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.

Original languageEnglish (US)
Pages (from-to)469-486
Number of pages18
JournalSleep Medicine Clinics
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Neuropharmacology
Wakefulness
Hypnotics and Sedatives
Sleep
Pharmaceutical Preparations
Drug Design
Safety
Research

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Neuropharmacology of sleep and wakefulness : 2012 update. / Watson, Christopher J.; Baghdoyan, Helen; Lydic, Ralph.

In: Sleep Medicine Clinics, Vol. 7, No. 3, 01.01.2012, p. 469-486.

Research output: Contribution to journalReview article

@article{f769ebbb3096403cb43908ad39fc1050,
title = "Neuropharmacology of sleep and wakefulness: 2012 update",
abstract = "The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs, but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects, and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This article reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.",
author = "Watson, {Christopher J.} and Helen Baghdoyan and Ralph Lydic",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.jsmc.2012.06.010",
language = "English (US)",
volume = "7",
pages = "469--486",
journal = "Sleep Medicine Clinics",
issn = "1556-407X",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Neuropharmacology of sleep and wakefulness

T2 - 2012 update

AU - Watson, Christopher J.

AU - Baghdoyan, Helen

AU - Lydic, Ralph

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs, but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects, and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This article reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.

AB - The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs, but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects, and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This article reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.

UR - http://www.scopus.com/inward/record.url?scp=84865708025&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865708025&partnerID=8YFLogxK

U2 - 10.1016/j.jsmc.2012.06.010

DO - 10.1016/j.jsmc.2012.06.010

M3 - Review article

VL - 7

SP - 469

EP - 486

JO - Sleep Medicine Clinics

JF - Sleep Medicine Clinics

SN - 1556-407X

IS - 3

ER -