Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats

Behavioral, neurochemical and immunohistochemical studies

Gulrana Khuwaja, Mohd Moshahid Khan, Tauheed Ishrat, Ajmal Ahmad, Syed Shadab Raza, Mohammad Ashafaq, Hayate Javed, M. Badruzzaman Khan, Andleeb Khan, Kumar Vaibhav, Mohammed M. Safhi, Fakhrul Islam

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Curcumin, the active principle of turmeric used in Indian curry is known for its antitumor, antioxidant, antiarthritic, anti-ischemic and anti-inflammatory properties and might inhibit the accumulation of destructive beta-amyloid in the brains of Alzheimer's disease patients. A Parkinsonian model in rats was developed by giving 6-hydroxydopamine (10 μg/2 μl in 0.1% ascorbic acid-saline) in the right striatum. After 3 weeks of lesioning, the behavior activities (rotarod, narrow beam test, grip test and contra-lateral rotations) were increased in a lesioned group as compared to a sham group and these activities were protected significantly with the pretreatment of curcumin. A significant protection on lipid peroxidation, glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, tyrosine hydroxylase and D2 receptor binding was observed in the striatum of lesioned group animals pretreated with 80 mg/kg body weight of curcumin for 21 days as compared to lesion group animals. No significant alterations on behavior and biochemical parameters were observed in sham group animals and the animals of sham group pretreated with curcumin. This study indicates that curcumin, which is an important ingredient of diet in India and also used in various systems of indigenous medicine, is helpful in preventing Parkinsonism and has therapeutic potential in combating this devastating neurologic disorder.

Original languageEnglish (US)
Pages (from-to)254-263
Number of pages10
JournalBrain Research
Volume1368
DOIs
StatePublished - Jan 12 2011

Fingerprint

Curcumin
Oxidopamine
Parkinsonian Disorders
Neuroprotective Agents
Curcuma
Glutathione Reductase
Tyrosine 3-Monooxygenase
Brain Diseases
Traditional Medicine
Hand Strength
Glutathione Peroxidase
Systems Analysis
Nervous System Diseases
Amyloid
Catalase
Lipid Peroxidation
Ascorbic Acid
Superoxide Dismutase
Glutathione
India

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats : Behavioral, neurochemical and immunohistochemical studies. / Khuwaja, Gulrana; Khan, Mohd Moshahid; Ishrat, Tauheed; Ahmad, Ajmal; Raza, Syed Shadab; Ashafaq, Mohammad; Javed, Hayate; Khan, M. Badruzzaman; Khan, Andleeb; Vaibhav, Kumar; Safhi, Mohammed M.; Islam, Fakhrul.

In: Brain Research, Vol. 1368, 12.01.2011, p. 254-263.

Research output: Contribution to journalArticle

Khuwaja, G, Khan, MM, Ishrat, T, Ahmad, A, Raza, SS, Ashafaq, M, Javed, H, Khan, MB, Khan, A, Vaibhav, K, Safhi, MM & Islam, F 2011, 'Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies', Brain Research, vol. 1368, pp. 254-263. https://doi.org/10.1016/j.brainres.2010.10.023
Khuwaja, Gulrana ; Khan, Mohd Moshahid ; Ishrat, Tauheed ; Ahmad, Ajmal ; Raza, Syed Shadab ; Ashafaq, Mohammad ; Javed, Hayate ; Khan, M. Badruzzaman ; Khan, Andleeb ; Vaibhav, Kumar ; Safhi, Mohammed M. ; Islam, Fakhrul. / Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats : Behavioral, neurochemical and immunohistochemical studies. In: Brain Research. 2011 ; Vol. 1368. pp. 254-263.
@article{4da2654b97364b0ba4827dc041052b44,
title = "Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies",
abstract = "Curcumin, the active principle of turmeric used in Indian curry is known for its antitumor, antioxidant, antiarthritic, anti-ischemic and anti-inflammatory properties and might inhibit the accumulation of destructive beta-amyloid in the brains of Alzheimer's disease patients. A Parkinsonian model in rats was developed by giving 6-hydroxydopamine (10 μg/2 μl in 0.1{\%} ascorbic acid-saline) in the right striatum. After 3 weeks of lesioning, the behavior activities (rotarod, narrow beam test, grip test and contra-lateral rotations) were increased in a lesioned group as compared to a sham group and these activities were protected significantly with the pretreatment of curcumin. A significant protection on lipid peroxidation, glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, tyrosine hydroxylase and D2 receptor binding was observed in the striatum of lesioned group animals pretreated with 80 mg/kg body weight of curcumin for 21 days as compared to lesion group animals. No significant alterations on behavior and biochemical parameters were observed in sham group animals and the animals of sham group pretreated with curcumin. This study indicates that curcumin, which is an important ingredient of diet in India and also used in various systems of indigenous medicine, is helpful in preventing Parkinsonism and has therapeutic potential in combating this devastating neurologic disorder.",
author = "Gulrana Khuwaja and Khan, {Mohd Moshahid} and Tauheed Ishrat and Ajmal Ahmad and Raza, {Syed Shadab} and Mohammad Ashafaq and Hayate Javed and Khan, {M. Badruzzaman} and Andleeb Khan and Kumar Vaibhav and Safhi, {Mohammed M.} and Fakhrul Islam",
year = "2011",
month = "1",
day = "12",
doi = "10.1016/j.brainres.2010.10.023",
language = "English (US)",
volume = "1368",
pages = "254--263",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats

T2 - Behavioral, neurochemical and immunohistochemical studies

AU - Khuwaja, Gulrana

AU - Khan, Mohd Moshahid

AU - Ishrat, Tauheed

AU - Ahmad, Ajmal

AU - Raza, Syed Shadab

AU - Ashafaq, Mohammad

AU - Javed, Hayate

AU - Khan, M. Badruzzaman

AU - Khan, Andleeb

AU - Vaibhav, Kumar

AU - Safhi, Mohammed M.

AU - Islam, Fakhrul

PY - 2011/1/12

Y1 - 2011/1/12

N2 - Curcumin, the active principle of turmeric used in Indian curry is known for its antitumor, antioxidant, antiarthritic, anti-ischemic and anti-inflammatory properties and might inhibit the accumulation of destructive beta-amyloid in the brains of Alzheimer's disease patients. A Parkinsonian model in rats was developed by giving 6-hydroxydopamine (10 μg/2 μl in 0.1% ascorbic acid-saline) in the right striatum. After 3 weeks of lesioning, the behavior activities (rotarod, narrow beam test, grip test and contra-lateral rotations) were increased in a lesioned group as compared to a sham group and these activities were protected significantly with the pretreatment of curcumin. A significant protection on lipid peroxidation, glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, tyrosine hydroxylase and D2 receptor binding was observed in the striatum of lesioned group animals pretreated with 80 mg/kg body weight of curcumin for 21 days as compared to lesion group animals. No significant alterations on behavior and biochemical parameters were observed in sham group animals and the animals of sham group pretreated with curcumin. This study indicates that curcumin, which is an important ingredient of diet in India and also used in various systems of indigenous medicine, is helpful in preventing Parkinsonism and has therapeutic potential in combating this devastating neurologic disorder.

AB - Curcumin, the active principle of turmeric used in Indian curry is known for its antitumor, antioxidant, antiarthritic, anti-ischemic and anti-inflammatory properties and might inhibit the accumulation of destructive beta-amyloid in the brains of Alzheimer's disease patients. A Parkinsonian model in rats was developed by giving 6-hydroxydopamine (10 μg/2 μl in 0.1% ascorbic acid-saline) in the right striatum. After 3 weeks of lesioning, the behavior activities (rotarod, narrow beam test, grip test and contra-lateral rotations) were increased in a lesioned group as compared to a sham group and these activities were protected significantly with the pretreatment of curcumin. A significant protection on lipid peroxidation, glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, tyrosine hydroxylase and D2 receptor binding was observed in the striatum of lesioned group animals pretreated with 80 mg/kg body weight of curcumin for 21 days as compared to lesion group animals. No significant alterations on behavior and biochemical parameters were observed in sham group animals and the animals of sham group pretreated with curcumin. This study indicates that curcumin, which is an important ingredient of diet in India and also used in various systems of indigenous medicine, is helpful in preventing Parkinsonism and has therapeutic potential in combating this devastating neurologic disorder.

UR - http://www.scopus.com/inward/record.url?scp=78651068527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651068527&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2010.10.023

DO - 10.1016/j.brainres.2010.10.023

M3 - Article

VL - 1368

SP - 254

EP - 263

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -