Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment

M. Badruzzaman Khan, Md Nasrul Hoda, Tauheed Ishrat, Saif Ahmad, Mohd Moshahid Khan, Ajmal Ahmad, Seema Yusuf, Fakhrul Islam

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Oxidative stress leads to complex biochemical alterations, and has been implicated in the progressive loss of learning and memory. Supplementing and boosting the endogenous antioxidant defense system could impede the progression of various types of neurodegeneration. In the present study, we have investigated the neuroprotective efficacy of a low-dose combination of certain promising and powerful natural antioxidants in an experimental model of cognitive impairment.Combined pretreatmentwith the extract ofNardosatchys jatamansi (N), crocetin (C) and selenium(Se) as sodium selenite (N, 200 mg/kg + C, 25 μg/kg + Se, 0.05 mg/kg body weight) for 15 days led to improved behavioral outcomes in streptozotocin (STZ)-induced cognitive impairment in rats. While intracerebroventricular (ICV) infusion of STZ resulted in the significant elevation ofmarkers of oxidative stress and depletion of endogenous antioxidant defense system in the vehicle-pretreated group, these markers of oxidative stress and antioxidant enzymatic as well as nonenzymatic defense lines were attenuated in the group pretreated with the combination of antioxidants (NCSe). NCSe pretreatment markedly improved the performance of animals in passive avoidance test and Morris water maze (MWM) tasks, significantly reduced the level of TBARS, and elevated the content of glutathione and activities of antioxidant enzymes (glutathione peroxidase, glutathione-S-transferase and catalase).Our study reflects the synergistic potential of the above combination and concludes that amultimodal approach could be beneficial rather than a singular intervention.

Original languageEnglish (US)
Pages (from-to)1011-1020
Number of pages10
JournalNeurological Sciences
Volume33
Issue number5
DOIs
StatePublished - Oct 1 2012

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Nardostachys
Selenium
Antioxidants
Oxidative Stress
Streptozocin
Intraventricular Infusions
Sodium Selenite
Memory Disorders
Glutathione Peroxidase
Glutathione Transferase
Catalase
Glutathione
crocetin
Cognitive Dysfunction
Theoretical Models
Body Weight
Learning
Water

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment. / Khan, M. Badruzzaman; Hoda, Md Nasrul; Ishrat, Tauheed; Ahmad, Saif; Khan, Mohd Moshahid; Ahmad, Ajmal; Yusuf, Seema; Islam, Fakhrul.

In: Neurological Sciences, Vol. 33, No. 5, 01.10.2012, p. 1011-1020.

Research output: Contribution to journalArticle

Khan, M. Badruzzaman ; Hoda, Md Nasrul ; Ishrat, Tauheed ; Ahmad, Saif ; Khan, Mohd Moshahid ; Ahmad, Ajmal ; Yusuf, Seema ; Islam, Fakhrul. / Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment. In: Neurological Sciences. 2012 ; Vol. 33, No. 5. pp. 1011-1020.
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