Neuroprotective properties of ketone bodies

Kui Xu, Joseph C. Lamanna, Michelle Puchowicz

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Ketosis, as with fasting or induced by ketogenic diet, continues to be explored as a strategy toward the treatment of neuropathologies and disease. Exogenous administration of anaplerotic compounds has shown promise as they rescue oxidatively stressed tissues and has shown to improve overall function in liver and heart, but little is known about their application in brain. Precursors of propionyl-CoA such as odd-chain fatty acids (propionate, heptanoate) as well as odd-chain C4 and C5 have been changed to C4 and C5 consistently. Please check.C5-ketone bodies (β-keto and R-β-hydroxypentanoate) are potential anaplerotic substrates as these compounds are metabolized to propionyl-CoA that enters the citric acid cycle as succinyl-CoA. We have recently reported that ketosis was neuroprotective against transient focal ischemia. In this study, we present data that support the use of alternate energy substrates such as propionate and ketone bodies, as part of treatment regimes against ischemia-reperfusion injury. We propose that anaplerotic compounds are beneficial to recovery of brain following an ischemic event, such as with transient global or focal brain ischemia. We present data from two in vivo models of transient brain ischemia, cardiac arrest and resuscitation and focal stroke (via MCAO) where either ketosis induced by ketogenic diet (C4 ketosis) or infusion of propionate ester (N,S-dipropionyl cysteine ethyl ester) resulted in improved outcome following ischemic insult.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXIII
Pages97-102
Number of pages6
Volume737
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume737
ISSN (Print)0065-2598

Fingerprint

Ketone Bodies
Ketosis
Brain
Propionates
Ketogenic Diet
Nutrition
Brain Ischemia
Heptanoates
Resuscitation
Citric Acid Cycle
Substrates
Heart Arrest
Reperfusion Injury
Human Body
Liver
Fasting
Esters
Fatty Acids
Ischemia
Stroke

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Xu, K., Lamanna, J. C., & Puchowicz, M. (2012). Neuroprotective properties of ketone bodies. In Oxygen Transport to Tissue XXXIII (Vol. 737, pp. 97-102). (Advances in Experimental Medicine and Biology; Vol. 737). https://doi.org/10.1007/978-1-4614-1566-4_15

Neuroprotective properties of ketone bodies. / Xu, Kui; Lamanna, Joseph C.; Puchowicz, Michelle.

Oxygen Transport to Tissue XXXIII. Vol. 737 2012. p. 97-102 (Advances in Experimental Medicine and Biology; Vol. 737).

Research output: Chapter in Book/Report/Conference proceedingChapter

Xu, K, Lamanna, JC & Puchowicz, M 2012, Neuroprotective properties of ketone bodies. in Oxygen Transport to Tissue XXXIII. vol. 737, Advances in Experimental Medicine and Biology, vol. 737, pp. 97-102. https://doi.org/10.1007/978-1-4614-1566-4_15
Xu K, Lamanna JC, Puchowicz M. Neuroprotective properties of ketone bodies. In Oxygen Transport to Tissue XXXIII. Vol. 737. 2012. p. 97-102. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-1566-4_15
Xu, Kui ; Lamanna, Joseph C. ; Puchowicz, Michelle. / Neuroprotective properties of ketone bodies. Oxygen Transport to Tissue XXXIII. Vol. 737 2012. pp. 97-102 (Advances in Experimental Medicine and Biology).
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