Neuropsychiatric complications after liver transplantation

Role of immunosuppression and hepatitis C

Claudio Tombazzi, Bradford Waters, M. Hosein Shokouh-Amiri, Santiago R. Vera, Caroline A. Riely

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Neuropsychiatric complications are an important source of morbidity following orthotopic liver transplantation. Etiology of liver disease and type of immunosuppression are possible related factors. The aim of this study was to describe the prevalence of neuropsychiatric complications after liver transplantation, the role of immunosuppression, and the association between these and specific liver diseases such as hepatitis C. One hundred twenty-eight patients with liver transplants were studied. Tacrolimus was the primary immunosuppressant in 101 patients and cyclosporine in 27 patients. Seventy-five complications in 49 patients (38.2%) were reported. In 43 patients, the etiology was associated with immunosuppression: 36 on tacrolimus and 7 on cyclosporine (P = 0.34). Seventeen and four-tenths percent of patients with hepatitis C and 4.6% of patients without hepatitis C developed depression (P = 0.02). There is no difference between types of primary immunosuppression and neuropsychiatric complications. There is a significantly greater incidence of depression in patients transplanted for hepatitis C.

Original languageEnglish (US)
Pages (from-to)1079-1081
Number of pages3
JournalDigestive Diseases and Sciences
Volume51
Issue number6
DOIs
StatePublished - Jun 1 2006

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Hepatitis C
Liver Transplantation
Immunosuppression
Tacrolimus
Cyclosporine
Liver Diseases
Immunosuppressive Agents
Morbidity
Transplants
Liver
Incidence

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Neuropsychiatric complications after liver transplantation : Role of immunosuppression and hepatitis C. / Tombazzi, Claudio; Waters, Bradford; Shokouh-Amiri, M. Hosein; Vera, Santiago R.; Riely, Caroline A.

In: Digestive Diseases and Sciences, Vol. 51, No. 6, 01.06.2006, p. 1079-1081.

Research output: Contribution to journalArticle

Tombazzi, Claudio ; Waters, Bradford ; Shokouh-Amiri, M. Hosein ; Vera, Santiago R. ; Riely, Caroline A. / Neuropsychiatric complications after liver transplantation : Role of immunosuppression and hepatitis C. In: Digestive Diseases and Sciences. 2006 ; Vol. 51, No. 6. pp. 1079-1081.
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