Neurotransmitter control of hypothalamic-pituitary-thyroid functions in rats

John E. Morley, Gary L. Brammer, Burt Sharp, Tadataka Yamada, Arthur Yuwiler, Jerome M. Hershman

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The possible roles of monoamine neurotransmitters in the regulation of the hypothalamic-pituitary-thyroid axis were examined in the rat. Rats were treated acutely and repeatedly with drugs which are presumed to alter neutransmitter functional activity. These drugs include neurotransmitter precursors (tryptophan and L-DOPA), synthesis inhibitors (p-chlorophenylamine and α-methyltyrosine), uptake inhibitors (desipramine and zimelidine) and lithium carbonate. The hormone levels measured were hypothalamic TRH and SLI content and serum TSH, T4 and T3. We conclude that augmented serotogenic or dopaminergic activity may inhibit TRH release, but that release from these inhibitors is not sufficient to stimulate TRH release. Resease of TRH seems to be mediated by norepinephrine. Lithium treatment results in increased hypothalamic TRH.

Original languageEnglish (US)
Pages (from-to)263-271
Number of pages9
JournalEuropean Journal of Pharmacology
Volume70
Issue number3
DOIs
StatePublished - Mar 26 1981

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Methyltyrosines
Neurotransmitter Agents
Thyroid Gland
Zimeldine
Lithium Carbonate
Desipramine
Lithium
Tryptophan
Pharmaceutical Preparations
Norepinephrine
Hormones
Serum
4-chloroaniline

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Neurotransmitter control of hypothalamic-pituitary-thyroid functions in rats. / Morley, John E.; Brammer, Gary L.; Sharp, Burt; Yamada, Tadataka; Yuwiler, Arthur; Hershman, Jerome M.

In: European Journal of Pharmacology, Vol. 70, No. 3, 26.03.1981, p. 263-271.

Research output: Contribution to journalArticle

Morley, John E. ; Brammer, Gary L. ; Sharp, Burt ; Yamada, Tadataka ; Yuwiler, Arthur ; Hershman, Jerome M. / Neurotransmitter control of hypothalamic-pituitary-thyroid functions in rats. In: European Journal of Pharmacology. 1981 ; Vol. 70, No. 3. pp. 263-271.
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