Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome

Nishant Dwivedi, Marko Radic

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Felty's syndrome (FS) is a severe arthritic disorder that features chronic neutrophil activation and progresses to neutropenia and susceptibility to unabated infections. The life-threatening manifestations of FS have focused the attention of clinical experimenters who have made persistent efforts to find new and effective therapies. This review highlights important milestones in the research on FS and draws attention to recent studies on the antigen specificity of antibodies present in patients' sera. Recent data have indicated that immunoglobulins G (IgGs) in patients with FS bind selectively and specifically to deiminated histones and neutrophil extracellular chromatin traps (NETs). Deimination is the conversion of certain arginine residues in proteins to citrullines by the enzyme peptidylarginine deiminase 4. Earlier observations had indicated that IgGs in FS patients avidly bind to citrullinated peptides. These observations suggest that NETosis, the type of cell death that is defined by the release of NETs, provides autoantigens that stimulate B cell responses in this patient group. This insight parallels recent observations in other autoimmune conditions and lends support to the paradigm that NETosis plays a leading role in the pathogenesis of antiself immune responses. Copyright by Medycyna Praktyczna, 2012.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalPolskie Archiwum Medycyny Wewnetrznej
Volume122
Issue number7-8
StatePublished - 2012

Fingerprint

Felty Syndrome
Neutrophil Activation
B-Lymphocytes
Chromatin
Immunoglobulin G
Citrulline
Antibody Specificity
Autoantigens
Neutropenia
Histones
Arthritis
Arginine
Cell Death
Antigens
Peptides
Enzymes
Infection
Serum
Research
Proteins

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. / Dwivedi, Nishant; Radic, Marko.

In: Polskie Archiwum Medycyny Wewnetrznej, Vol. 122, No. 7-8, 2012, p. 374-379.

Research output: Contribution to journalReview article

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abstract = "Felty's syndrome (FS) is a severe arthritic disorder that features chronic neutrophil activation and progresses to neutropenia and susceptibility to unabated infections. The life-threatening manifestations of FS have focused the attention of clinical experimenters who have made persistent efforts to find new and effective therapies. This review highlights important milestones in the research on FS and draws attention to recent studies on the antigen specificity of antibodies present in patients' sera. Recent data have indicated that immunoglobulins G (IgGs) in patients with FS bind selectively and specifically to deiminated histones and neutrophil extracellular chromatin traps (NETs). Deimination is the conversion of certain arginine residues in proteins to citrullines by the enzyme peptidylarginine deiminase 4. Earlier observations had indicated that IgGs in FS patients avidly bind to citrullinated peptides. These observations suggest that NETosis, the type of cell death that is defined by the release of NETs, provides autoantigens that stimulate B cell responses in this patient group. This insight parallels recent observations in other autoimmune conditions and lends support to the paradigm that NETosis plays a leading role in the pathogenesis of antiself immune responses. Copyright by Medycyna Praktyczna, 2012.",
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AB - Felty's syndrome (FS) is a severe arthritic disorder that features chronic neutrophil activation and progresses to neutropenia and susceptibility to unabated infections. The life-threatening manifestations of FS have focused the attention of clinical experimenters who have made persistent efforts to find new and effective therapies. This review highlights important milestones in the research on FS and draws attention to recent studies on the antigen specificity of antibodies present in patients' sera. Recent data have indicated that immunoglobulins G (IgGs) in patients with FS bind selectively and specifically to deiminated histones and neutrophil extracellular chromatin traps (NETs). Deimination is the conversion of certain arginine residues in proteins to citrullines by the enzyme peptidylarginine deiminase 4. Earlier observations had indicated that IgGs in FS patients avidly bind to citrullinated peptides. These observations suggest that NETosis, the type of cell death that is defined by the release of NETs, provides autoantigens that stimulate B cell responses in this patient group. This insight parallels recent observations in other autoimmune conditions and lends support to the paradigm that NETosis plays a leading role in the pathogenesis of antiself immune responses. Copyright by Medycyna Praktyczna, 2012.

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