Neutrophil CD64 as a diagnostic marker of sepsis: Impact on neonatal care

Stephanie Lynema, Daniel Marmer, Eric S. Hall, Jareen Meinzen-Derr, Paul S. Kingma

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective The aim of this study is to determine the validity and reliability of neutrophil CD64 in identifying infected infants and to evaluate the impact of this marker on clinical care. Study Design Neutrophil CD64 index was incorporated in 371 infection evaluations in 234 infants (ages 1-293 days) from 2005 to 2009 and the impact of this change on clinical care was evaluated. Results The sensitivity of the neutrophil CD64 assay was 87% in identifying 31 episodes of culture positive sepsis and 83% in identifying 12 infants with ventilator-associated pneumonia. There was no difference in the mean number of antibiotic days in infants with a normal CD64 versus those with a normal complete blood count (CBC) (p = 0.89), but twofold more infants were identified as not infected by CD64 than by CBC. Conclusion CD64 had a high sensitivity for identifying infected infants while also decreasing the number of infants that were exposed to unnecessary antibiotic use

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalAmerican Journal of Perinatology
Volume32
Issue number4
DOIs
StatePublished - Jan 1 2014

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Sepsis
Neutrophils
Blood Cell Count
Anti-Bacterial Agents
Ventilator-Associated Pneumonia
Reproducibility of Results
Biomarkers
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Neutrophil CD64 as a diagnostic marker of sepsis : Impact on neonatal care. / Lynema, Stephanie; Marmer, Daniel; Hall, Eric S.; Meinzen-Derr, Jareen; Kingma, Paul S.

In: American Journal of Perinatology, Vol. 32, No. 4, 01.01.2014, p. 331-336.

Research output: Contribution to journalArticle

Lynema, Stephanie ; Marmer, Daniel ; Hall, Eric S. ; Meinzen-Derr, Jareen ; Kingma, Paul S. / Neutrophil CD64 as a diagnostic marker of sepsis : Impact on neonatal care. In: American Journal of Perinatology. 2014 ; Vol. 32, No. 4. pp. 331-336.
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