Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: A prospective observational study

Gokhan Gungor, Huseyin Ataseven, Ali Demir, Yalcin Solak, Abduzhappar Gaipov, Murat Biyik, Bahadir Ozturk, Ilker Polat, Aysel Kiyici, Ozlem O. Cakir, Hakki Polat

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background & Aims: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis which is characterized by renal dysfunction and associated with poor survival. Neutrophil gelatinase-associated lipocalin (NGAL) is a troponin-like biomarker for human acute kidney injury. We aimed to investigate levels of plasma and urine NGAL in HRS and predictive ability of these markers for all-cause mortality, in HRS, stable cirrhosis and control subjects. Methods: A total of 64 patients with cirrhosis (8 patients with type 1 HRS, 22 with type 2 HRS, and 34 without HRS) and 23 control subjects were included in the study. Blood and urine samples were measured with Human NGAL sandwich ELISA. Patients were followed up prospectively. Results: Patients with type 1 and type 2 HRS had significantly higher plasma and urine NGAL levels compared with stable cirrhosis and control subjects. Cox regression analysis showed that plasma NGAL and MELD-Na scores were independent predictors of mortality. ROC-curve analysis showed that the plot of the plasma NGAL, urine NGAL, MELD-Na and Child-Turcot-Pugh score could predict all-cause mortality in cirrhotic patients' area under the curve (AUC 0.819, 0.686, 0.807 and 0.795 respectively). Conclusions: NGAL could predict mortality in patients with HRS independent of other commonly used risk factors.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalLiver International
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2014

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Hepatorenal Syndrome
Observational Studies
Prospective Studies
Mortality
Fibrosis
Urine
ROC Curve
Area Under Curve
Troponin
Lipocalin-2
Acute Kidney Injury
Biomarkers
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Kidney
Survival

All Science Journal Classification (ASJC) codes

  • Hepatology

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Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome : A prospective observational study. / Gungor, Gokhan; Ataseven, Huseyin; Demir, Ali; Solak, Yalcin; Gaipov, Abduzhappar; Biyik, Murat; Ozturk, Bahadir; Polat, Ilker; Kiyici, Aysel; Cakir, Ozlem O.; Polat, Hakki.

In: Liver International, Vol. 34, No. 1, 01.01.2014, p. 49-57.

Research output: Contribution to journalArticle

Gungor, G, Ataseven, H, Demir, A, Solak, Y, Gaipov, A, Biyik, M, Ozturk, B, Polat, I, Kiyici, A, Cakir, OO & Polat, H 2014, 'Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome: A prospective observational study', Liver International, vol. 34, no. 1, pp. 49-57. https://doi.org/10.1111/liv.12232
Gungor, Gokhan ; Ataseven, Huseyin ; Demir, Ali ; Solak, Yalcin ; Gaipov, Abduzhappar ; Biyik, Murat ; Ozturk, Bahadir ; Polat, Ilker ; Kiyici, Aysel ; Cakir, Ozlem O. ; Polat, Hakki. / Neutrophil gelatinase-associated lipocalin in prediction of mortality in patients with hepatorenal syndrome : A prospective observational study. In: Liver International. 2014 ; Vol. 34, No. 1. pp. 49-57.
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AU - Demir, Ali

AU - Solak, Yalcin

AU - Gaipov, Abduzhappar

AU - Biyik, Murat

AU - Ozturk, Bahadir

AU - Polat, Ilker

AU - Kiyici, Aysel

AU - Cakir, Ozlem O.

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AB - Background & Aims: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis which is characterized by renal dysfunction and associated with poor survival. Neutrophil gelatinase-associated lipocalin (NGAL) is a troponin-like biomarker for human acute kidney injury. We aimed to investigate levels of plasma and urine NGAL in HRS and predictive ability of these markers for all-cause mortality, in HRS, stable cirrhosis and control subjects. Methods: A total of 64 patients with cirrhosis (8 patients with type 1 HRS, 22 with type 2 HRS, and 34 without HRS) and 23 control subjects were included in the study. Blood and urine samples were measured with Human NGAL sandwich ELISA. Patients were followed up prospectively. Results: Patients with type 1 and type 2 HRS had significantly higher plasma and urine NGAL levels compared with stable cirrhosis and control subjects. Cox regression analysis showed that plasma NGAL and MELD-Na scores were independent predictors of mortality. ROC-curve analysis showed that the plot of the plasma NGAL, urine NGAL, MELD-Na and Child-Turcot-Pugh score could predict all-cause mortality in cirrhotic patients' area under the curve (AUC 0.819, 0.686, 0.807 and 0.795 respectively). Conclusions: NGAL could predict mortality in patients with HRS independent of other commonly used risk factors.

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