New 2-benzoxazolinone derivatives with cytotoxic activities from the roots of acanthus ilicifolius

Dan Zhao, Lijun Xie, Lei Yu, Ni An, Wei Na, Feng Chen, Youbin Li, Yinfeng Tan, Xiaopo Zhang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four new 2-benzoxazolinone-type alkaloids (acanthosides A-D) along with three known ones were isolated from the roots of Acanthus ilicifolius. Their structures were established by detailed interpretation of one dimensional (1D)- and two dimensional (2D)-NMR as well as high-resolution electrospray ionization (ESI)-MS data. The antiproliferative activities of these compounds were evaluated in vitro against three cultured cancer cell lines. The new compounds exhibited different levels of cytotoxicity against the HepG2, HeLa, and A-549 cancer cell lines with IC 50 range 7.8-26.6 μm. In comparison with known compounds, the new isolates displayed better cytotoxic activities, which was attributable to the presence of substituted benzoyl moiety in their structures.

Original languageEnglish (US)
Pages (from-to)1087-1090
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume63
Issue number12
DOIs
StatePublished - Dec 1 2015

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Acanthaceae
Cells
Derivatives
Cell Line
Electrospray ionization
Cytotoxicity
Alkaloids
Cultured Cells
Neoplasms
Nuclear magnetic resonance
benzoxazolone

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

New 2-benzoxazolinone derivatives with cytotoxic activities from the roots of acanthus ilicifolius. / Zhao, Dan; Xie, Lijun; Yu, Lei; An, Ni; Na, Wei; Chen, Feng; Li, Youbin; Tan, Yinfeng; Zhang, Xiaopo.

In: Chemical and Pharmaceutical Bulletin, Vol. 63, No. 12, 01.12.2015, p. 1087-1090.

Research output: Contribution to journalArticle

Zhao, D, Xie, L, Yu, L, An, N, Na, W, Chen, F, Li, Y, Tan, Y & Zhang, X 2015, 'New 2-benzoxazolinone derivatives with cytotoxic activities from the roots of acanthus ilicifolius', Chemical and Pharmaceutical Bulletin, vol. 63, no. 12, pp. 1087-1090. https://doi.org/10.1248/cpb.c15-00597
Zhao, Dan ; Xie, Lijun ; Yu, Lei ; An, Ni ; Na, Wei ; Chen, Feng ; Li, Youbin ; Tan, Yinfeng ; Zhang, Xiaopo. / New 2-benzoxazolinone derivatives with cytotoxic activities from the roots of acanthus ilicifolius. In: Chemical and Pharmaceutical Bulletin. 2015 ; Vol. 63, No. 12. pp. 1087-1090.
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