New adolescent polycystic ovary syndrome perspectives

Ramin Alemzadeh, A. R. Kansra

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is a common but heterogeneous disorder that usually arises during puberty. This endocrine disorder is associated with chronic anovulation and hyperandrogenemia with clinical manifestation of oligomenorrhea, hirsutism and acne. While the underlying etiology of PCOS remains unknown, it is commonly associated with obesity and insulin resistance leading to increased risk of cardiovascular disease, dyslipidemia and type 2 diabetes mellitus in hyperandrogenemic phenotypes. Menstrual irregularities and insulin resistance in obese adolescents are usually indistinguishable from the clinical manifestations of PCOS and pose a diagnostic dilemma due to higher circulating androgens during puberty. Consequently, a universal consensus on the definition of hyperandrogenemia in adolescents has been elusive. Nevertheless, hyperandrogenemia, independent of obesity, in postmenarchal adolescents is associated with increased risk of cardiometabolic syndrome. Therefore, treatment strategies including lifestyle changes and/or use of insulin-sensitizers, hormone replacement and antiandrogens should be utilized in order to delay long-term cardiovascular and metabolic complications of this endocrinopathy.

Original languageEnglish (US)
Pages (from-to)35-47
Number of pages13
JournalMinerva Pediatrica
Volume63
Issue number1
StatePublished - Feb 2011
Externally publishedYes

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Polycystic Ovary Syndrome
Puberty
Insulin Resistance
Obesity
Oligomenorrhea
Anovulation
Androgen Antagonists
Hirsutism
Acne Vulgaris
Dyslipidemias
Type 2 Diabetes Mellitus
Androgens
Life Style
Consensus
Cardiovascular Diseases
Hormones
Insulin
Phenotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

New adolescent polycystic ovary syndrome perspectives. / Alemzadeh, Ramin; Kansra, A. R.

In: Minerva Pediatrica, Vol. 63, No. 1, 02.2011, p. 35-47.

Research output: Contribution to journalReview article

Alemzadeh, Ramin ; Kansra, A. R. / New adolescent polycystic ovary syndrome perspectives. In: Minerva Pediatrica. 2011 ; Vol. 63, No. 1. pp. 35-47.
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