New and Old World hantaviruses differentially utilize host cytoskeletal components during their life cycles

Harish N. Ramanathan, Colleen Jonsson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Recently we reported that the N protein of the Old World hantavirus, Hantaan (HTNV), traffics on microtubules to the ER-Golgi intermediate compartment (ERGIC) prior to its movement to the Golgi and requires an intact ERGIC for viral replication. We have extended these studies to the New World hantaviruses, Andes virus (ANDV) and Black Creek Canal virus (BCCV), and an additional Old World hantavirus, Seoul virus (SEOV). These studies support microtubule-dependent trafficking of the N protein to ERGIC within the perinuclear region for the New and Old World hantaviruses. However, we observed that early entry events were distinct for HTNV and ANDV with respect to the pathway for entry and the dependence on an intact actin (ANDV) versus microtubule (HTNV) cytoskeleton for viral replication. These studies show for the first time that while Old and New World hantaviruses share common features in their pathways, they have evolved differences in their interaction with host cell machinery.

Original languageEnglish (US)
Pages (from-to)138-150
Number of pages13
JournalVirology
Volume374
Issue number1
DOIs
StatePublished - Apr 25 2008

Fingerprint

Hantavirus
Life Cycle Stages
Microtubules
Seoul virus
Protein Transport
Cytoskeleton
Actins
Viruses

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

New and Old World hantaviruses differentially utilize host cytoskeletal components during their life cycles. / Ramanathan, Harish N.; Jonsson, Colleen.

In: Virology, Vol. 374, No. 1, 25.04.2008, p. 138-150.

Research output: Contribution to journalArticle

@article{81f1d707729044b9a6d1022106ed6cbe,
title = "New and Old World hantaviruses differentially utilize host cytoskeletal components during their life cycles",
abstract = "Recently we reported that the N protein of the Old World hantavirus, Hantaan (HTNV), traffics on microtubules to the ER-Golgi intermediate compartment (ERGIC) prior to its movement to the Golgi and requires an intact ERGIC for viral replication. We have extended these studies to the New World hantaviruses, Andes virus (ANDV) and Black Creek Canal virus (BCCV), and an additional Old World hantavirus, Seoul virus (SEOV). These studies support microtubule-dependent trafficking of the N protein to ERGIC within the perinuclear region for the New and Old World hantaviruses. However, we observed that early entry events were distinct for HTNV and ANDV with respect to the pathway for entry and the dependence on an intact actin (ANDV) versus microtubule (HTNV) cytoskeleton for viral replication. These studies show for the first time that while Old and New World hantaviruses share common features in their pathways, they have evolved differences in their interaction with host cell machinery.",
author = "Ramanathan, {Harish N.} and Colleen Jonsson",
year = "2008",
month = "4",
day = "25",
doi = "10.1016/j.virol.2007.12.030",
language = "English (US)",
volume = "374",
pages = "138--150",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - New and Old World hantaviruses differentially utilize host cytoskeletal components during their life cycles

AU - Ramanathan, Harish N.

AU - Jonsson, Colleen

PY - 2008/4/25

Y1 - 2008/4/25

N2 - Recently we reported that the N protein of the Old World hantavirus, Hantaan (HTNV), traffics on microtubules to the ER-Golgi intermediate compartment (ERGIC) prior to its movement to the Golgi and requires an intact ERGIC for viral replication. We have extended these studies to the New World hantaviruses, Andes virus (ANDV) and Black Creek Canal virus (BCCV), and an additional Old World hantavirus, Seoul virus (SEOV). These studies support microtubule-dependent trafficking of the N protein to ERGIC within the perinuclear region for the New and Old World hantaviruses. However, we observed that early entry events were distinct for HTNV and ANDV with respect to the pathway for entry and the dependence on an intact actin (ANDV) versus microtubule (HTNV) cytoskeleton for viral replication. These studies show for the first time that while Old and New World hantaviruses share common features in their pathways, they have evolved differences in their interaction with host cell machinery.

AB - Recently we reported that the N protein of the Old World hantavirus, Hantaan (HTNV), traffics on microtubules to the ER-Golgi intermediate compartment (ERGIC) prior to its movement to the Golgi and requires an intact ERGIC for viral replication. We have extended these studies to the New World hantaviruses, Andes virus (ANDV) and Black Creek Canal virus (BCCV), and an additional Old World hantavirus, Seoul virus (SEOV). These studies support microtubule-dependent trafficking of the N protein to ERGIC within the perinuclear region for the New and Old World hantaviruses. However, we observed that early entry events were distinct for HTNV and ANDV with respect to the pathway for entry and the dependence on an intact actin (ANDV) versus microtubule (HTNV) cytoskeleton for viral replication. These studies show for the first time that while Old and New World hantaviruses share common features in their pathways, they have evolved differences in their interaction with host cell machinery.

UR - http://www.scopus.com/inward/record.url?scp=41649095179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41649095179&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2007.12.030

DO - 10.1016/j.virol.2007.12.030

M3 - Article

VL - 374

SP - 138

EP - 150

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -