New frontiers in aerosol delivery during mechanical ventilation.

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

The scientific basis for inhalation therapy in mechanically-ventilated patients is now firmly established. A variety of new devices that deliver drugs to the lung with high efficiency could be employed for drug delivery during mechanical ventilation. Encapsulation of drugs within liposomes could increase the amount of drug delivered, prolong the effect of a dose, and minimize adverse effects. With improved inhalation devices and surfactant formulations, inhaled surfactant could be employed for several indications in mechanically-ventilated patients. Research is unraveling the causes of some disorders that have been poorly understood, and our improved understanding of the causal mechanisms of various respiratory disorders will provide new applications for inhaled therapies.

Original languageEnglish (US)
Pages (from-to)666-677
Number of pages12
JournalRespiratory Care
Volume49
Issue number6
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Aerosols
Artificial Respiration
Surface-Active Agents
Pharmaceutical Preparations
Respiratory Therapy
Nebulizers and Vaporizers
Liposomes
Equipment and Supplies
Lung
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

New frontiers in aerosol delivery during mechanical ventilation. / Dhand, Rajiv.

In: Respiratory Care, Vol. 49, No. 6, 06.2004, p. 666-677.

Research output: Contribution to journalReview article

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