New understanding in cardiotoxicity

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Interest in cardiotoxicity has dramatically increased during the past two years, leading to exciting progress in our understanding of the field. Both clinical and experimental animal studies have emphasized the role of cardiotoxicity in myocardial pathogenesis. Exploration of the cardiotoxicity of air pollution and highly active antiretroviral therapy (HAART) through experimental animal studies have led to mechanistic insights. Novel therapeutic approaches are also under development. Continued efforts to investigate the mechanisms of cardiotoxicity induced by well-known drugs and chemicals, such as Adriamycin, have also generated critical insights into cardiac response to toxicants. Recognition of the significance of cardiotoxicity in myocardial pathogenesis has resulted in the identification of many other drugs or chemicals, such as arsenic trioxide, whose cardiotoxicity is of major concern in clinical applications. Mitochondrial cardiomyopathy, along with control of myocardial cell death, has also become an extensively studied subject. Ionic transport across the inner membrane of mitochondria, especially the function of mitochondrial ATP-sensitive IC channels and the Ca2+-activated IC channels in myocardial protection against oxidative injury, has attracted a great deal of attention. Novel approaches, such as functional genomics, proteomics and metabonomics, should significantly improve our understanding of cardiotoxicity.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalCurrent Opinion in Drug Discovery and Development
Volume6
Issue number1
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Metabolomics
Highly Active Antiretroviral Therapy
Air Pollution
Genomics
Cardiotoxicity
Cardiomyopathies
Pharmaceutical Preparations
Proteomics
Doxorubicin
Mitochondria
Cell Death
Adenosine Triphosphate
Membranes
Wounds and Injuries
Therapeutics
arsenic trioxide

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

Cite this

New understanding in cardiotoxicity. / Kang, Yujian.

In: Current Opinion in Drug Discovery and Development, Vol. 6, No. 1, 01.01.2003, p. 110-116.

Research output: Contribution to journalReview article

@article{30471086feb1444eaf38bf7413dfb998,
title = "New understanding in cardiotoxicity",
abstract = "Interest in cardiotoxicity has dramatically increased during the past two years, leading to exciting progress in our understanding of the field. Both clinical and experimental animal studies have emphasized the role of cardiotoxicity in myocardial pathogenesis. Exploration of the cardiotoxicity of air pollution and highly active antiretroviral therapy (HAART) through experimental animal studies have led to mechanistic insights. Novel therapeutic approaches are also under development. Continued efforts to investigate the mechanisms of cardiotoxicity induced by well-known drugs and chemicals, such as Adriamycin, have also generated critical insights into cardiac response to toxicants. Recognition of the significance of cardiotoxicity in myocardial pathogenesis has resulted in the identification of many other drugs or chemicals, such as arsenic trioxide, whose cardiotoxicity is of major concern in clinical applications. Mitochondrial cardiomyopathy, along with control of myocardial cell death, has also become an extensively studied subject. Ionic transport across the inner membrane of mitochondria, especially the function of mitochondrial ATP-sensitive IC channels and the Ca2+-activated IC channels in myocardial protection against oxidative injury, has attracted a great deal of attention. Novel approaches, such as functional genomics, proteomics and metabonomics, should significantly improve our understanding of cardiotoxicity.",
author = "Yujian Kang",
year = "2003",
month = "1",
day = "1",
language = "English (US)",
volume = "6",
pages = "110--116",
journal = "Current Opinion in Drug Discovery and Development",
issn = "1367-6733",
publisher = "Current Drugs Ltd.",
number = "1",

}

TY - JOUR

T1 - New understanding in cardiotoxicity

AU - Kang, Yujian

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Interest in cardiotoxicity has dramatically increased during the past two years, leading to exciting progress in our understanding of the field. Both clinical and experimental animal studies have emphasized the role of cardiotoxicity in myocardial pathogenesis. Exploration of the cardiotoxicity of air pollution and highly active antiretroviral therapy (HAART) through experimental animal studies have led to mechanistic insights. Novel therapeutic approaches are also under development. Continued efforts to investigate the mechanisms of cardiotoxicity induced by well-known drugs and chemicals, such as Adriamycin, have also generated critical insights into cardiac response to toxicants. Recognition of the significance of cardiotoxicity in myocardial pathogenesis has resulted in the identification of many other drugs or chemicals, such as arsenic trioxide, whose cardiotoxicity is of major concern in clinical applications. Mitochondrial cardiomyopathy, along with control of myocardial cell death, has also become an extensively studied subject. Ionic transport across the inner membrane of mitochondria, especially the function of mitochondrial ATP-sensitive IC channels and the Ca2+-activated IC channels in myocardial protection against oxidative injury, has attracted a great deal of attention. Novel approaches, such as functional genomics, proteomics and metabonomics, should significantly improve our understanding of cardiotoxicity.

AB - Interest in cardiotoxicity has dramatically increased during the past two years, leading to exciting progress in our understanding of the field. Both clinical and experimental animal studies have emphasized the role of cardiotoxicity in myocardial pathogenesis. Exploration of the cardiotoxicity of air pollution and highly active antiretroviral therapy (HAART) through experimental animal studies have led to mechanistic insights. Novel therapeutic approaches are also under development. Continued efforts to investigate the mechanisms of cardiotoxicity induced by well-known drugs and chemicals, such as Adriamycin, have also generated critical insights into cardiac response to toxicants. Recognition of the significance of cardiotoxicity in myocardial pathogenesis has resulted in the identification of many other drugs or chemicals, such as arsenic trioxide, whose cardiotoxicity is of major concern in clinical applications. Mitochondrial cardiomyopathy, along with control of myocardial cell death, has also become an extensively studied subject. Ionic transport across the inner membrane of mitochondria, especially the function of mitochondrial ATP-sensitive IC channels and the Ca2+-activated IC channels in myocardial protection against oxidative injury, has attracted a great deal of attention. Novel approaches, such as functional genomics, proteomics and metabonomics, should significantly improve our understanding of cardiotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0037277191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037277191&partnerID=8YFLogxK

M3 - Review article

C2 - 12613282

AN - SCOPUS:0037277191

VL - 6

SP - 110

EP - 116

JO - Current Opinion in Drug Discovery and Development

JF - Current Opinion in Drug Discovery and Development

SN - 1367-6733

IS - 1

ER -