Nimodipine posttreatment does not increase blood flow in rats with focal cortical ischemia

Ulrich Dimagi, Michael Jacewicz, William Pulsinelli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We used laser-Doppler fiowmetry to study the effect of nimodipine administered after the onset of focal cortical ischemia on regional cerebral blood flow in 16 halothane-anesthetized, mechanically ventilated Wistar rats. We selected the Wistar rat strain since it would provide a wide range of ischemia severities to test the vascular response to nimodipine. laser-Doppler probes continuously recorded regional cerebral blood flow at two or three sites over the parietal cortex (dura intact) while brain temperature was regulated at 37° C. Occlusion of the right middle cerebral and common carotid arteries reduced cerebral blood flow to a mean of 38% (range 13-77%) of baseline. Thirty minutes later, either 2/ig/kg/min nimodipine (n=8) or its vehicle, polyethylene glycol 400 (n =8), was administered by a continuous intravenous infusion. Over 60 minutes of treatment, both the nimodipine-treated and vehicle-treated groups showed a trivial (3%) mean increase in cerebral blood flow. Nimodipine failed to augment cerebral blood flow regardless of whether the cortex was severely, moderately, or mildly ischemic.

Original languageEnglish (US)
Pages (from-to)1357-1361
Number of pages5
JournalStroke
Volume21
Issue number9
StatePublished - Jan 1 1990

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Cerebrovascular Circulation
Nimodipine
Ischemia
Regional Blood Flow
Wistar Rats
Lasers
Parietal Lobe
Common Carotid Artery
Halothane
Intravenous Infusions
Blood Vessels
Temperature
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Nimodipine posttreatment does not increase blood flow in rats with focal cortical ischemia. / Dimagi, Ulrich; Jacewicz, Michael; Pulsinelli, William.

In: Stroke, Vol. 21, No. 9, 01.01.1990, p. 1357-1361.

Research output: Contribution to journalArticle

Dimagi, Ulrich ; Jacewicz, Michael ; Pulsinelli, William. / Nimodipine posttreatment does not increase blood flow in rats with focal cortical ischemia. In: Stroke. 1990 ; Vol. 21, No. 9. pp. 1357-1361.
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