Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia

Michael Jacewicz, Steve Brint, Jody Tanabe, Xing Je Wang, William A. Pulsinelli

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The effect of nimodipine pretreatment on CBF and brain edema was studied in conscious rats subjected to 2.5 h of focal cortical ischemia. An infusion of nimodipine (2 μg/kg/min i.v.) or its vehicle, polyethylene glycol 400, was begun 2 h before the ischemic interval and was continued throughout the survival period. Under brief halothane anesthesia, the animals' right middle cerebral and common carotid arteries were permanently occluded, and 2.5 h later, they underwent a quantitative CBF study ([14C]iodoantipyrine autoradiography followed by Quantimet 970 image analysis). Nimodipine treatment improved blood flow to the middle cerebral artery territory without evidence of a "vascular steal" and reduced the volume of the ischemic core (cortex with CBF of < 25 ml/100 g/min) and accompanying edema by ∼50% when compared with controls (p = 0.006 and 0.0004, respectively). Mild hypotension induced by nimodipine did not aggravate the ischemic insult. The ischemic core volumes, however, were 50-75% smaller than the 24-h infarct volumes generated in a similar paradigm that demonstrated 20-30% infarct reduction with continuous nimodipine treatment. These results suggest that nimodipine pretreatment attenuates the severity of early focal cerebral ischemia, but that with persistent ischemia, cortex surrounding the ischemic core undergoes progressive infarction and the early benefit of nimodipine treatment is only partly preserved.

Original languageEnglish (US)
Pages (from-to)903-913
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume10
Issue number6
DOIs
StatePublished - Jan 1 1990

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Cerebrovascular Circulation
Nimodipine
Brain Edema
Brain Ischemia
Ischemia
Animal Rights
Controlled Hypotension
Common Carotid Artery
Middle Cerebral Artery
Halothane
Autoradiography
Infarction
Blood Vessels
Edema
Anesthesia

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Nimodipine pretreatment improves cerebral blood flow and reduces brain edema in conscious rats subjected to focal cerebral ischemia. / Jacewicz, Michael; Brint, Steve; Tanabe, Jody; Wang, Xing Je; Pulsinelli, William A.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 10, No. 6, 01.01.1990, p. 903-913.

Research output: Contribution to journalArticle

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