Nitrogen balance and protein requirements for critically Ill older patients

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Critically ill older patients with sarcopenia experience greater morbidity and mortality than younger patients. It is anticipated that unabated protein catabolism would be detrimental for the critically ill older patient. Healthy older subjects experience a diminished response to protein supplementation when compared to their younger counterparts, but this anabolic resistance can be overcome by increasing protein intake. Preliminary evidence suggests that older patients may respond differently to protein intake than younger patients during critical illness as well. If sufficient protein intake is given, older patients can achieve a similar nitrogen accretion response as younger patients even during critical illness. However, there is concern among some clinicians that increasing protein intake in older patients during critical illness may lead to azotemia due to decreased renal functional reserve which may augment the propensity towards worsened renal function and worsened clinical outcomes. Current evidence regarding protein requirements, nitrogen balance, ureagenesis, and clinical outcomes during nutritional therapy for critically ill older patients is reviewed.

Original languageEnglish (US)
Article number56
JournalNutrients
Volume8
Issue number4
DOIs
StatePublished - Apr 18 2016

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protein requirement
nitrogen balance
Critical Illness
Nitrogen
protein intake
Proteins
sarcopenia
Sarcopenia
Azotemia
Kidney
diet therapy
uremia
protein supplements
renal function
protein metabolism
morbidity
Healthy Volunteers
kidneys
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Nitrogen balance and protein requirements for critically Ill older patients. / Dickerson, Roland.

In: Nutrients, Vol. 8, No. 4, 56, 18.04.2016.

Research output: Contribution to journalReview article

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