Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia

Peter Mckeown, J. S. McClelland, D. K. Bone, E. L. Jones, J. A. Kaplan, J. F. Lutz, C. R. Hatcher, R. A. Guyton

Research output: Contribution to journalArticle

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Abstract

The efficacy of nitroglycerin as an adjunct to hyperkalemic hypothermic cardioplegia was assessed by measurement of changes in coronary vascular resistance. Thirty patients undergoing coronary artery bypass grafting were studied. During a 1000 ml infusion of cardioplegia, a bolus of 1 mg of nitroglycerine or control solution was injected while the infusion rate was kept constant. Measurement of aortic root pressure allowed calculation of coronary vascular resistance. There was a mean decrease of 21.2% in coronary vascular resistance after a bolus of 1 mg of nitroglycerin was injected in the study group (p < .001, n = 15); there was no significant change in resistance in the control group. There was also no significant change in systemic vascular resistance in either group. A retrospective blind analysis of the anatomic angiographic features of the heart with a quantitative assessment of both coronary stenoses and coronary collaterals was made. There was no correlation between coronary scores and preinjection coronary vascular resistance. There was also no correlation between collateral scores and the change in coronary vascular resistance with nitroglycerin. These results suggest that nitroglycerin is an effective coronary vasodilator when used as an adjunct in hypothermic hyperkalemic cardioplegia and that baseline coronary vascular resistance or change in coronary vascular resistance with nitroglycerin cannot be predicted on the basis of current assessments of coronary angiograms.

Original languageEnglish (US)
JournalCirculation
Volume68
Issue number3 II
StatePublished - Oct 21 1983
Externally publishedYes

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Induced Heart Arrest
Nitroglycerin
Vascular Resistance
Coronary Stenosis
Vasodilator Agents
Coronary Artery Bypass
Angiography
Arterial Pressure
Control Groups

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mckeown, P., McClelland, J. S., Bone, D. K., Jones, E. L., Kaplan, J. A., Lutz, J. F., ... Guyton, R. A. (1983). Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia. Circulation, 68(3 II).

Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia. / Mckeown, Peter; McClelland, J. S.; Bone, D. K.; Jones, E. L.; Kaplan, J. A.; Lutz, J. F.; Hatcher, C. R.; Guyton, R. A.

In: Circulation, Vol. 68, No. 3 II, 21.10.1983.

Research output: Contribution to journalArticle

Mckeown, P, McClelland, JS, Bone, DK, Jones, EL, Kaplan, JA, Lutz, JF, Hatcher, CR & Guyton, RA 1983, 'Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia', Circulation, vol. 68, no. 3 II.
Mckeown P, McClelland JS, Bone DK, Jones EL, Kaplan JA, Lutz JF et al. Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia. Circulation. 1983 Oct 21;68(3 II).
Mckeown, Peter ; McClelland, J. S. ; Bone, D. K. ; Jones, E. L. ; Kaplan, J. A. ; Lutz, J. F. ; Hatcher, C. R. ; Guyton, R. A. / Nitroglycerin as an adjunct to hypothermic hyperkalemic cardioplegia. In: Circulation. 1983 ; Vol. 68, No. 3 II.
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