No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population

Logan Dumitrescu, Cara L. Carty, Nora Franceschini, Lucia A. Hindorff, Shelley A. Cole, Petra Bůžková, Fredrick R. Schumacher, Charles B. Eaton, Robert J. Goodloe, David J. Duggan, Jeff Haessler, Barbara Cochran, Brian E. Henderson, Iona Cheng, Karen Johnson, Chris S. Carlson, Shelly Anne Love, Kristin Brown-Gentry, Alejandro Q. Nato, Miguel Quibrera & 10 others Ralph V. Shohet, José Luis Ambite, Lynne R. Wilkens, Loïc Le Marchand, Christopher A. Haiman, Steven Buyske, Charles Kooperberg, Kari E. North, Myriam Fornage, Dana C. Crawford

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.

Original languageEnglish (US)
Pages (from-to)1427-1431
Number of pages5
JournalHuman genetics
Volume132
Issue number12
DOIs
StatePublished - Dec 1 2013

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Metagenomics
Epidemiology
Genome-Wide Association Study
Smoking
Lipids
Population
Genetic Association Studies
Genomics
LDL Cholesterol
HDL Cholesterol
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Dumitrescu, L., Carty, C. L., Franceschini, N., Hindorff, L. A., Cole, S. A., Bůžková, P., ... Crawford, D. C. (2013). No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. Human genetics, 132(12), 1427-1431. https://doi.org/10.1007/s00439-013-1375-3

No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. / Dumitrescu, Logan; Carty, Cara L.; Franceschini, Nora; Hindorff, Lucia A.; Cole, Shelley A.; Bůžková, Petra; Schumacher, Fredrick R.; Eaton, Charles B.; Goodloe, Robert J.; Duggan, David J.; Haessler, Jeff; Cochran, Barbara; Henderson, Brian E.; Cheng, Iona; Johnson, Karen; Carlson, Chris S.; Love, Shelly Anne; Brown-Gentry, Kristin; Nato, Alejandro Q.; Quibrera, Miguel; Shohet, Ralph V.; Ambite, José Luis; Wilkens, Lynne R.; Le Marchand, Loïc; Haiman, Christopher A.; Buyske, Steven; Kooperberg, Charles; North, Kari E.; Fornage, Myriam; Crawford, Dana C.

In: Human genetics, Vol. 132, No. 12, 01.12.2013, p. 1427-1431.

Research output: Contribution to journalArticle

Dumitrescu, L, Carty, CL, Franceschini, N, Hindorff, LA, Cole, SA, Bůžková, P, Schumacher, FR, Eaton, CB, Goodloe, RJ, Duggan, DJ, Haessler, J, Cochran, B, Henderson, BE, Cheng, I, Johnson, K, Carlson, CS, Love, SA, Brown-Gentry, K, Nato, AQ, Quibrera, M, Shohet, RV, Ambite, JL, Wilkens, LR, Le Marchand, L, Haiman, CA, Buyske, S, Kooperberg, C, North, KE, Fornage, M & Crawford, DC 2013, 'No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population', Human genetics, vol. 132, no. 12, pp. 1427-1431. https://doi.org/10.1007/s00439-013-1375-3
Dumitrescu, Logan ; Carty, Cara L. ; Franceschini, Nora ; Hindorff, Lucia A. ; Cole, Shelley A. ; Bůžková, Petra ; Schumacher, Fredrick R. ; Eaton, Charles B. ; Goodloe, Robert J. ; Duggan, David J. ; Haessler, Jeff ; Cochran, Barbara ; Henderson, Brian E. ; Cheng, Iona ; Johnson, Karen ; Carlson, Chris S. ; Love, Shelly Anne ; Brown-Gentry, Kristin ; Nato, Alejandro Q. ; Quibrera, Miguel ; Shohet, Ralph V. ; Ambite, José Luis ; Wilkens, Lynne R. ; Le Marchand, Loïc ; Haiman, Christopher A. ; Buyske, Steven ; Kooperberg, Charles ; North, Kari E. ; Fornage, Myriam ; Crawford, Dana C. / No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. In: Human genetics. 2013 ; Vol. 132, No. 12. pp. 1427-1431.
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