Nociception before and after exercise in rats bred for high and low aerobic capacity

Michael E. Geisser, Wenfei Wang, Matthew Smuck, Lauren G. Koch, Steven L. Britton, Ralph Lydic

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Exercise and stress are known to influence pain perception. However, little is known about how level of fitness influences pain perception and the experience of pain. In the present study, pain perception before and after exercise to exhaustion was examined in 6 rats systematically bred to have a high aerobic capacity (HCR animals) and 6 rats systematically bred to have a low aerobic capacity (LCR animals). HCR animals had significantly higher pain thresholds compared to LCR animals before and after exercise (7.66 s compared to 6.01 s, t = -3.07, p < 0.05; and 6.89 s versus 4.73 s, t = -3.73, p < 0.01, respectively). In addition, both groups of animals displayed evidence of hyperalgesia following exercise compared to baseline. However, the pain thresholds of HCR animals returned to baseline levels faster than LCR animals following exercise. The findings support the hypothesis that level of fitness plays a role in the perception of pain. In addition, a higher level of fitness may serve as buffer against the effects of stress and help to reduce or prevent the experience of clinical pain. Further research is needed to examine the mechanisms that underlie this phenomenon.

Original languageEnglish (US)
Pages (from-to)37-40
Number of pages4
JournalNeuroscience Letters
Volume443
Issue number1
DOIs
StatePublished - Sep 26 2008

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Nociception
Pain Perception
Pain Threshold
Pain
Hyperalgesia
Buffers
Research

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nociception before and after exercise in rats bred for high and low aerobic capacity. / Geisser, Michael E.; Wang, Wenfei; Smuck, Matthew; Koch, Lauren G.; Britton, Steven L.; Lydic, Ralph.

In: Neuroscience Letters, Vol. 443, No. 1, 26.09.2008, p. 37-40.

Research output: Contribution to journalArticle

Geisser, Michael E. ; Wang, Wenfei ; Smuck, Matthew ; Koch, Lauren G. ; Britton, Steven L. ; Lydic, Ralph. / Nociception before and after exercise in rats bred for high and low aerobic capacity. In: Neuroscience Letters. 2008 ; Vol. 443, No. 1. pp. 37-40.
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