Non-conventional signal transduction by type I interferons

The NF-κB pathway

Ziyun Du, Lai Wei, Aruna Murti, Susan R. Pfeffer, Meiyun Fan, Chuan Yang, Lawrence Pfeffer

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Type I interferons (IFNs) regulate diverse cellular functions by modulating the expression of IFN-stimulated genes (ISGs) through the activation of the well established signal transduction pathway of the Janus Kinase (JAK) and signal transducers and activators of transcription (STAT) proteins. Although the JAK-STAT signal transduction pathway is critical in mediating IFN's antiviral and antiproliferative activities, other signaling pathways are activated by IFNs and regulate cellular response to IFN. The NF-κB transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel IFN mediated signal pathway that leads to NF-κB activation and demonstrate that a subset of ISGs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in ISG expression, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.

Original languageEnglish (US)
Pages (from-to)1087-1094
Number of pages8
JournalJournal of Cellular Biochemistry
Volume102
Issue number5
DOIs
StatePublished - Dec 1 2007

Fingerprint

Signal transduction
Interferon Type I
Interferons
Signal Transduction
Janus Kinases
Genes
Chemical activation
Antiviral Agents
STAT Transcription Factors
Gene Expression
Transcription
Transducers
Gene expression
Transcriptional Activation
Communicable Diseases
Cell Survival
Transcription Factors
Cells
Apoptosis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Non-conventional signal transduction by type I interferons : The NF-κB pathway. / Du, Ziyun; Wei, Lai; Murti, Aruna; Pfeffer, Susan R.; Fan, Meiyun; Yang, Chuan; Pfeffer, Lawrence.

In: Journal of Cellular Biochemistry, Vol. 102, No. 5, 01.12.2007, p. 1087-1094.

Research output: Contribution to journalReview article

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AU - Fan, Meiyun

AU - Yang, Chuan

AU - Pfeffer, Lawrence

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