Noneffect of rifampin on theophylline disposition in rabbits

T. H. Self, M. M. Self, J. P. Worden, W. S. Taylor, A. B. Straughn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pharmacokinetic disposition of theophylline after a single 10 mg/kg intravenous dose of aminophylline was evaluated in six rabbits. Three then received rifampin (50mg/kg) a day for 14 days and the disposition of theophylline was re-evaluated in all six rabbits after another 10 mg/kg aminophylline dose. The mean theophylline half life before rifampin treatment of 5.11 ± 0.71 hrs was not different (p > 0.10) from the half life of 4.54 ± 0.71 hrs after treatment with rifampin. In the non-rifampin treated rabbits, the initial mean theophylline half life of 4.78 ± 1.05 was not different (p > 0.80) from the half life of 4.94 ± 1.92 hrs after fourteen days. No significant alterations in clearance or area under the curve were noted for either group. Power analysis indicated that three rabbits were sufficient to detect at least a 25% change in the parameters as being significant (p < 0.05).

Original languageEnglish (US)
Pages (from-to)505-508
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume38
Issue number3
StatePublished - Dec 1 1982

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Rifampin
Theophylline
Half-Life
Rabbits
Aminophylline
Pharmacokinetics
Area Under Curve

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Self, T. H., Self, M. M., Worden, J. P., Taylor, W. S., & Straughn, A. B. (1982). Noneffect of rifampin on theophylline disposition in rabbits. Research Communications in Chemical Pathology and Pharmacology, 38(3), 505-508.

Noneffect of rifampin on theophylline disposition in rabbits. / Self, T. H.; Self, M. M.; Worden, J. P.; Taylor, W. S.; Straughn, A. B.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 38, No. 3, 01.12.1982, p. 505-508.

Research output: Contribution to journalArticle

Self, TH, Self, MM, Worden, JP, Taylor, WS & Straughn, AB 1982, 'Noneffect of rifampin on theophylline disposition in rabbits', Research Communications in Chemical Pathology and Pharmacology, vol. 38, no. 3, pp. 505-508.
Self TH, Self MM, Worden JP, Taylor WS, Straughn AB. Noneffect of rifampin on theophylline disposition in rabbits. Research Communications in Chemical Pathology and Pharmacology. 1982 Dec 1;38(3):505-508.
Self, T. H. ; Self, M. M. ; Worden, J. P. ; Taylor, W. S. ; Straughn, A. B. / Noneffect of rifampin on theophylline disposition in rabbits. In: Research Communications in Chemical Pathology and Pharmacology. 1982 ; Vol. 38, No. 3. pp. 505-508.
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