Nonencapsulated, intact omeprazole granules effectively suppress intragastric acidity when administered via a gastrostomy

Virender K. Sharma, Eric J. Heinzelmann, Eric N. Steinberg, Rajeev Vasudeva, Colin Howden

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Because of its acid-labile nature, omeprazole is usually administered as encapsulated enteric-coated granules. The gelatin capsule and acid-resistant coating are essential for effective drug absorption and optimal bioavailability. Objective: This study tested the effectiveness of nonencapsulated, intact omeprazole granules in suppressing intragastric acidity when administered through a gastrostomy. Methods: Fourteen male patients with established gastrostomies underwent a baseline 24-h intragastric pH monitoring study while off any acid-suppressing medication. Via the gastrostomy, they then received 7 days of dosing with 20 mg omeprazole as intact granules in orange juice. Twenty-four-hour intragastric pH monitoring was repeated on the seventh day. Results: Mean intragastric pH during the baseline study was 1.8 (± SD 0.7). This pH increased to 4.9 ± 0.8 with omeprazole granules (p < 0.0001). Median intragastric pH rose from 1.3 to 5.3 (p < 0.0001). During the baseline study, intragastric pH was above 3 for 21.2 ± 14.1%, above 4 for 14.9 ± 11.0%, and above 5 for 9.5 ± 8.4% of the 24-h recording period. Corresponding values after 7 days of omeprazole were 80 ± 15.1%, 72.5 ± 16.3%, and 59.1 ± 16.6% (p < 0.0001 for each comparison with pretreatment values). Conclusion: Omeprazole effectively suppresses intragastric acidity when given through a gastrostomy tube as nonencapsulated, intact granules.

Original languageEnglish (US)
Pages (from-to)848-851
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume92
Issue number5
StatePublished - May 1 1997

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Gastrostomy
Omeprazole
Acids
Essential Drugs
Gelatin
Biological Availability
Capsules

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Nonencapsulated, intact omeprazole granules effectively suppress intragastric acidity when administered via a gastrostomy. / Sharma, Virender K.; Heinzelmann, Eric J.; Steinberg, Eric N.; Vasudeva, Rajeev; Howden, Colin.

In: American Journal of Gastroenterology, Vol. 92, No. 5, 01.05.1997, p. 848-851.

Research output: Contribution to journalArticle

Sharma, Virender K. ; Heinzelmann, Eric J. ; Steinberg, Eric N. ; Vasudeva, Rajeev ; Howden, Colin. / Nonencapsulated, intact omeprazole granules effectively suppress intragastric acidity when administered via a gastrostomy. In: American Journal of Gastroenterology. 1997 ; Vol. 92, No. 5. pp. 848-851.
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abstract = "Because of its acid-labile nature, omeprazole is usually administered as encapsulated enteric-coated granules. The gelatin capsule and acid-resistant coating are essential for effective drug absorption and optimal bioavailability. Objective: This study tested the effectiveness of nonencapsulated, intact omeprazole granules in suppressing intragastric acidity when administered through a gastrostomy. Methods: Fourteen male patients with established gastrostomies underwent a baseline 24-h intragastric pH monitoring study while off any acid-suppressing medication. Via the gastrostomy, they then received 7 days of dosing with 20 mg omeprazole as intact granules in orange juice. Twenty-four-hour intragastric pH monitoring was repeated on the seventh day. Results: Mean intragastric pH during the baseline study was 1.8 (± SD 0.7). This pH increased to 4.9 ± 0.8 with omeprazole granules (p < 0.0001). Median intragastric pH rose from 1.3 to 5.3 (p < 0.0001). During the baseline study, intragastric pH was above 3 for 21.2 ± 14.1{\%}, above 4 for 14.9 ± 11.0{\%}, and above 5 for 9.5 ± 8.4{\%} of the 24-h recording period. Corresponding values after 7 days of omeprazole were 80 ± 15.1{\%}, 72.5 ± 16.3{\%}, and 59.1 ± 16.6{\%} (p < 0.0001 for each comparison with pretreatment values). Conclusion: Omeprazole effectively suppresses intragastric acidity when given through a gastrostomy tube as nonencapsulated, intact granules.",
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