Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection

Erich Cosmi, Giancarlo Mari, Loredana Delle Chiaie, Laura Detti, Masashi Akiyama, June Murphy, Theodor Stefos, James E. Ferguson, David Hunter, Chaur Dong Hsu, Alfred Abuhamad, Ray Bahado-Singh

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to evaluate the feasibility of the middle cerebral artery peak systolic velocity for the detection of fetal anemia in pregnancies that are complicated by parvovirus B19 infection. STUDY DESIGN: Doppler measurements of the middle cerebral artery peak systolic velocity were performed weekly in 32 fetuses at risk for anemia because of maternal parvovirus infection documented by the presence of serum immunoglobulin M antibody. The values of the middle cerebral artery peak systolic velocity and hemoglobin were expressed as multiples of the median. These values were plotted on reference ranges that had been established previously. A cordocentesis was performed either because of fetal ascites or when the middle cerebral artery peak systolic velocity values suggested anemia (middle cerebral artery peak systolic velocity, >1.50 multiples of the median). RESULTS: Gestational age at study entry ranged from 15.1 to 37 weeks. There were 17 fetuses with middle cerebral artery peak systolic velocity of >1.50 MoM (group 1). Sixteen cordocenteses were performed in these fetuses. All 16 fetuses were anemic (15 severely and 1 mildly). Thirteen fetuses had signs of hydrops (12 with severe and 1 with mild anemia). Group 2 included 15 fetuses with the middle cerebral artery peak systolic velocity values <1.50 MoM. Two cordocenteses were performed. One fetus was mildly anemic; the second fetus was not anemic. The remaining 13 fetuses of this group did not have any complications and were not anemic at birth. The sensitivity of the middle cerebral artery peak systolic velocity (<1.50 MoM) for the prediction of anemia because of parvovirus infection was 94.1%; the specificity was 93.3%; the positive and negative predictive values were 94.1% and 93.3%, respectively. CONCLUSION: Fetal anemia caused by parvovirus infection can be detected noninvasively by Doppler ultrasonography on the basis of an increase in the peak velocity of systolic blood flow in the middle cerebral artery.

Original languageEnglish (US)
Pages (from-to)1290-1293
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume187
Issue number5
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Parvoviridae Infections
Doppler Ultrasonography
Middle Cerebral Artery
Anemia
Fetus
Cordocentesis
Blood Flow Velocity
Ascites
Gestational Age
Immunoglobulin M
Edema
Reference Values
Hemoglobins
Mothers
Parturition
Pregnancy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. / Cosmi, Erich; Mari, Giancarlo; Chiaie, Loredana Delle; Detti, Laura; Akiyama, Masashi; Murphy, June; Stefos, Theodor; Ferguson, James E.; Hunter, David; Hsu, Chaur Dong; Abuhamad, Alfred; Bahado-Singh, Ray.

In: American Journal of Obstetrics and Gynecology, Vol. 187, No. 5, 01.11.2002, p. 1290-1293.

Research output: Contribution to journalArticle

Cosmi, E, Mari, G, Chiaie, LD, Detti, L, Akiyama, M, Murphy, J, Stefos, T, Ferguson, JE, Hunter, D, Hsu, CD, Abuhamad, A & Bahado-Singh, R 2002, 'Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection', American Journal of Obstetrics and Gynecology, vol. 187, no. 5, pp. 1290-1293. https://doi.org/10.1067/mob.2002.128024
Cosmi, Erich ; Mari, Giancarlo ; Chiaie, Loredana Delle ; Detti, Laura ; Akiyama, Masashi ; Murphy, June ; Stefos, Theodor ; Ferguson, James E. ; Hunter, David ; Hsu, Chaur Dong ; Abuhamad, Alfred ; Bahado-Singh, Ray. / Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection. In: American Journal of Obstetrics and Gynecology. 2002 ; Vol. 187, No. 5. pp. 1290-1293.
@article{40b01d25bfdd439c9a1bafab181181f5,
title = "Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection",
abstract = "OBJECTIVE: The purpose of this study was to evaluate the feasibility of the middle cerebral artery peak systolic velocity for the detection of fetal anemia in pregnancies that are complicated by parvovirus B19 infection. STUDY DESIGN: Doppler measurements of the middle cerebral artery peak systolic velocity were performed weekly in 32 fetuses at risk for anemia because of maternal parvovirus infection documented by the presence of serum immunoglobulin M antibody. The values of the middle cerebral artery peak systolic velocity and hemoglobin were expressed as multiples of the median. These values were plotted on reference ranges that had been established previously. A cordocentesis was performed either because of fetal ascites or when the middle cerebral artery peak systolic velocity values suggested anemia (middle cerebral artery peak systolic velocity, >1.50 multiples of the median). RESULTS: Gestational age at study entry ranged from 15.1 to 37 weeks. There were 17 fetuses with middle cerebral artery peak systolic velocity of >1.50 MoM (group 1). Sixteen cordocenteses were performed in these fetuses. All 16 fetuses were anemic (15 severely and 1 mildly). Thirteen fetuses had signs of hydrops (12 with severe and 1 with mild anemia). Group 2 included 15 fetuses with the middle cerebral artery peak systolic velocity values <1.50 MoM. Two cordocenteses were performed. One fetus was mildly anemic; the second fetus was not anemic. The remaining 13 fetuses of this group did not have any complications and were not anemic at birth. The sensitivity of the middle cerebral artery peak systolic velocity (<1.50 MoM) for the prediction of anemia because of parvovirus infection was 94.1{\%}; the specificity was 93.3{\%}; the positive and negative predictive values were 94.1{\%} and 93.3{\%}, respectively. CONCLUSION: Fetal anemia caused by parvovirus infection can be detected noninvasively by Doppler ultrasonography on the basis of an increase in the peak velocity of systolic blood flow in the middle cerebral artery.",
author = "Erich Cosmi and Giancarlo Mari and Chiaie, {Loredana Delle} and Laura Detti and Masashi Akiyama and June Murphy and Theodor Stefos and Ferguson, {James E.} and David Hunter and Hsu, {Chaur Dong} and Alfred Abuhamad and Ray Bahado-Singh",
year = "2002",
month = "11",
day = "1",
doi = "10.1067/mob.2002.128024",
language = "English (US)",
volume = "187",
pages = "1290--1293",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Noninvasive diagnosis by Doppler ultrasonography of fetal anemia resulting from parvovirus infection

AU - Cosmi, Erich

AU - Mari, Giancarlo

AU - Chiaie, Loredana Delle

AU - Detti, Laura

AU - Akiyama, Masashi

AU - Murphy, June

AU - Stefos, Theodor

AU - Ferguson, James E.

AU - Hunter, David

AU - Hsu, Chaur Dong

AU - Abuhamad, Alfred

AU - Bahado-Singh, Ray

PY - 2002/11/1

Y1 - 2002/11/1

N2 - OBJECTIVE: The purpose of this study was to evaluate the feasibility of the middle cerebral artery peak systolic velocity for the detection of fetal anemia in pregnancies that are complicated by parvovirus B19 infection. STUDY DESIGN: Doppler measurements of the middle cerebral artery peak systolic velocity were performed weekly in 32 fetuses at risk for anemia because of maternal parvovirus infection documented by the presence of serum immunoglobulin M antibody. The values of the middle cerebral artery peak systolic velocity and hemoglobin were expressed as multiples of the median. These values were plotted on reference ranges that had been established previously. A cordocentesis was performed either because of fetal ascites or when the middle cerebral artery peak systolic velocity values suggested anemia (middle cerebral artery peak systolic velocity, >1.50 multiples of the median). RESULTS: Gestational age at study entry ranged from 15.1 to 37 weeks. There were 17 fetuses with middle cerebral artery peak systolic velocity of >1.50 MoM (group 1). Sixteen cordocenteses were performed in these fetuses. All 16 fetuses were anemic (15 severely and 1 mildly). Thirteen fetuses had signs of hydrops (12 with severe and 1 with mild anemia). Group 2 included 15 fetuses with the middle cerebral artery peak systolic velocity values <1.50 MoM. Two cordocenteses were performed. One fetus was mildly anemic; the second fetus was not anemic. The remaining 13 fetuses of this group did not have any complications and were not anemic at birth. The sensitivity of the middle cerebral artery peak systolic velocity (<1.50 MoM) for the prediction of anemia because of parvovirus infection was 94.1%; the specificity was 93.3%; the positive and negative predictive values were 94.1% and 93.3%, respectively. CONCLUSION: Fetal anemia caused by parvovirus infection can be detected noninvasively by Doppler ultrasonography on the basis of an increase in the peak velocity of systolic blood flow in the middle cerebral artery.

AB - OBJECTIVE: The purpose of this study was to evaluate the feasibility of the middle cerebral artery peak systolic velocity for the detection of fetal anemia in pregnancies that are complicated by parvovirus B19 infection. STUDY DESIGN: Doppler measurements of the middle cerebral artery peak systolic velocity were performed weekly in 32 fetuses at risk for anemia because of maternal parvovirus infection documented by the presence of serum immunoglobulin M antibody. The values of the middle cerebral artery peak systolic velocity and hemoglobin were expressed as multiples of the median. These values were plotted on reference ranges that had been established previously. A cordocentesis was performed either because of fetal ascites or when the middle cerebral artery peak systolic velocity values suggested anemia (middle cerebral artery peak systolic velocity, >1.50 multiples of the median). RESULTS: Gestational age at study entry ranged from 15.1 to 37 weeks. There were 17 fetuses with middle cerebral artery peak systolic velocity of >1.50 MoM (group 1). Sixteen cordocenteses were performed in these fetuses. All 16 fetuses were anemic (15 severely and 1 mildly). Thirteen fetuses had signs of hydrops (12 with severe and 1 with mild anemia). Group 2 included 15 fetuses with the middle cerebral artery peak systolic velocity values <1.50 MoM. Two cordocenteses were performed. One fetus was mildly anemic; the second fetus was not anemic. The remaining 13 fetuses of this group did not have any complications and were not anemic at birth. The sensitivity of the middle cerebral artery peak systolic velocity (<1.50 MoM) for the prediction of anemia because of parvovirus infection was 94.1%; the specificity was 93.3%; the positive and negative predictive values were 94.1% and 93.3%, respectively. CONCLUSION: Fetal anemia caused by parvovirus infection can be detected noninvasively by Doppler ultrasonography on the basis of an increase in the peak velocity of systolic blood flow in the middle cerebral artery.

UR - http://www.scopus.com/inward/record.url?scp=0036854204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036854204&partnerID=8YFLogxK

U2 - 10.1067/mob.2002.128024

DO - 10.1067/mob.2002.128024

M3 - Article

VL - 187

SP - 1290

EP - 1293

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -