Noradrenergic modulation in the olfactory bulb influences spontaneous and reward-motivated discrimination, but not the formation of habituation memory

Nathalie Mandairon, Shane Peace, Alexandra Karnow, Jane Kim, Matthew Ennis, Christiane Linster

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine is involved in acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor dependent behaviors. Thus far, the role of norepinephrine in odor processing in adult rats remains less studied. We tested the role of noradrenergic modulation in the olfactory bulb of cannulated rats by bilateral injections of vehicle (6 μL saline), the α noradrenergic receptor antagonist phentolamine (3.15 or 10 mm), the β noradrenergic receptor antagonist alprenolol (12 or 120 mm), the α1 noradrenergic receptor antagonist prazosin (1 or 10-2 mm) and the α2 noradrenergic receptor antagonist yohimbine (2 or 0.02 mm) 20 min before two different behavioral tasks. We found that local blockade of noradrenergic receptors in the olfactory bulb did not affect the formation of habituation memory to an odorant over sequential presentations separated by 5-min intertrial intervals. However, spontaneous discrimination between chemically related odorants was impaired when noradrenergic receptors, and in particular α1 receptors, were blocked by local antagonist infusion into the olfactory bulb. By contrast, discrimination was improved when β receptors were blocked. These results show that although the formation of a habituation memory to odorants is not affected by noradrenergic modulation, the specificity of this memory is affected. In contrast, reward-motivated discrimination learning was not impaired, but slowed down in rats in which both α and β receptors had been blocked.

Original languageEnglish (US)
Pages (from-to)1210-1219
Number of pages10
JournalEuropean Journal of Neuroscience
Volume27
Issue number5
DOIs
StatePublished - Mar 1 2008

Fingerprint

Olfactory Bulb
Reward
Norepinephrine
Alprenolol
Newborn Animals
Discrimination Learning
Locus Coeruleus
Yohimbine
Prazosin
Phentolamine
Discrimination (Psychology)
Odorants
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Noradrenergic modulation in the olfactory bulb influences spontaneous and reward-motivated discrimination, but not the formation of habituation memory. / Mandairon, Nathalie; Peace, Shane; Karnow, Alexandra; Kim, Jane; Ennis, Matthew; Linster, Christiane.

In: European Journal of Neuroscience, Vol. 27, No. 5, 01.03.2008, p. 1210-1219.

Research output: Contribution to journalArticle

Mandairon, Nathalie ; Peace, Shane ; Karnow, Alexandra ; Kim, Jane ; Ennis, Matthew ; Linster, Christiane. / Noradrenergic modulation in the olfactory bulb influences spontaneous and reward-motivated discrimination, but not the formation of habituation memory. In: European Journal of Neuroscience. 2008 ; Vol. 27, No. 5. pp. 1210-1219.
@article{73f40c5fc26c40839233080ac3bf953e,
title = "Noradrenergic modulation in the olfactory bulb influences spontaneous and reward-motivated discrimination, but not the formation of habituation memory",
abstract = "The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine is involved in acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor dependent behaviors. Thus far, the role of norepinephrine in odor processing in adult rats remains less studied. We tested the role of noradrenergic modulation in the olfactory bulb of cannulated rats by bilateral injections of vehicle (6 μL saline), the α noradrenergic receptor antagonist phentolamine (3.15 or 10 mm), the β noradrenergic receptor antagonist alprenolol (12 or 120 mm), the α1 noradrenergic receptor antagonist prazosin (1 or 10-2 mm) and the α2 noradrenergic receptor antagonist yohimbine (2 or 0.02 mm) 20 min before two different behavioral tasks. We found that local blockade of noradrenergic receptors in the olfactory bulb did not affect the formation of habituation memory to an odorant over sequential presentations separated by 5-min intertrial intervals. However, spontaneous discrimination between chemically related odorants was impaired when noradrenergic receptors, and in particular α1 receptors, were blocked by local antagonist infusion into the olfactory bulb. By contrast, discrimination was improved when β receptors were blocked. These results show that although the formation of a habituation memory to odorants is not affected by noradrenergic modulation, the specificity of this memory is affected. In contrast, reward-motivated discrimination learning was not impaired, but slowed down in rats in which both α and β receptors had been blocked.",
author = "Nathalie Mandairon and Shane Peace and Alexandra Karnow and Jane Kim and Matthew Ennis and Christiane Linster",
year = "2008",
month = "3",
day = "1",
doi = "10.1111/j.1460-9568.2008.06101.x",
language = "English (US)",
volume = "27",
pages = "1210--1219",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Noradrenergic modulation in the olfactory bulb influences spontaneous and reward-motivated discrimination, but not the formation of habituation memory

AU - Mandairon, Nathalie

AU - Peace, Shane

AU - Karnow, Alexandra

AU - Kim, Jane

AU - Ennis, Matthew

AU - Linster, Christiane

PY - 2008/3/1

Y1 - 2008/3/1

N2 - The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine is involved in acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor dependent behaviors. Thus far, the role of norepinephrine in odor processing in adult rats remains less studied. We tested the role of noradrenergic modulation in the olfactory bulb of cannulated rats by bilateral injections of vehicle (6 μL saline), the α noradrenergic receptor antagonist phentolamine (3.15 or 10 mm), the β noradrenergic receptor antagonist alprenolol (12 or 120 mm), the α1 noradrenergic receptor antagonist prazosin (1 or 10-2 mm) and the α2 noradrenergic receptor antagonist yohimbine (2 or 0.02 mm) 20 min before two different behavioral tasks. We found that local blockade of noradrenergic receptors in the olfactory bulb did not affect the formation of habituation memory to an odorant over sequential presentations separated by 5-min intertrial intervals. However, spontaneous discrimination between chemically related odorants was impaired when noradrenergic receptors, and in particular α1 receptors, were blocked by local antagonist infusion into the olfactory bulb. By contrast, discrimination was improved when β receptors were blocked. These results show that although the formation of a habituation memory to odorants is not affected by noradrenergic modulation, the specificity of this memory is affected. In contrast, reward-motivated discrimination learning was not impaired, but slowed down in rats in which both α and β receptors had been blocked.

AB - The mammalian main olfactory bulb receives a significant noradrenergic input from the locus coeruleus. Norepinephrine is involved in acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor dependent behaviors. Thus far, the role of norepinephrine in odor processing in adult rats remains less studied. We tested the role of noradrenergic modulation in the olfactory bulb of cannulated rats by bilateral injections of vehicle (6 μL saline), the α noradrenergic receptor antagonist phentolamine (3.15 or 10 mm), the β noradrenergic receptor antagonist alprenolol (12 or 120 mm), the α1 noradrenergic receptor antagonist prazosin (1 or 10-2 mm) and the α2 noradrenergic receptor antagonist yohimbine (2 or 0.02 mm) 20 min before two different behavioral tasks. We found that local blockade of noradrenergic receptors in the olfactory bulb did not affect the formation of habituation memory to an odorant over sequential presentations separated by 5-min intertrial intervals. However, spontaneous discrimination between chemically related odorants was impaired when noradrenergic receptors, and in particular α1 receptors, were blocked by local antagonist infusion into the olfactory bulb. By contrast, discrimination was improved when β receptors were blocked. These results show that although the formation of a habituation memory to odorants is not affected by noradrenergic modulation, the specificity of this memory is affected. In contrast, reward-motivated discrimination learning was not impaired, but slowed down in rats in which both α and β receptors had been blocked.

UR - http://www.scopus.com/inward/record.url?scp=41149175693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41149175693&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2008.06101.x

DO - 10.1111/j.1460-9568.2008.06101.x

M3 - Article

VL - 27

SP - 1210

EP - 1219

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 5

ER -