Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb

Olga Escanilla, Adolfo Arrellanos, Alexandra Karnow, Matthew Ennis, Christiane Linster

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The mammalian main olfactory bulb (MOB) receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in the acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor-dependent behaviors. Thus far, the role of NE in odor processing in adult rats remains less studied. We investigated the role of noradrenergic modulation in the MOB on odor detection and discrimination thresholds using behavioral and computational modeling approaches. Adult rats received bilateral MOB injections of vehicle, NE (0.1-1000 μm), noradrenergic receptor antagonists and NE + receptor antagonists combined. NE infusion improved odor detection and discrimination as a function of NE and odor concentration. The effect of NE on detection and discrimination magnitude at any given odor concentration varied in a non-linear function with respect to NE concentration. Receptor antagonist infusion demonstrated that α1 receptor activation is necessary for the modulatory effect of NE. Computational modeling showed that increases in the strength of α1 receptor activation leads to improved odor signal-to-noise ratio and spike synchronization in mitral cells that may underlie the behaviorally observed decrease of detection and discrimination thresholds. Our results are the first to show that direct infusion of NE or noradrenergic receptor antagonists into a primary sensory network modulates sensory detection and discrimination thresholds at very low stimulus concentrations.

Original languageEnglish (US)
Pages (from-to)458-468
Number of pages11
JournalEuropean Journal of Neuroscience
Volume32
Issue number3
DOIs
StatePublished - Aug 1 2010

Fingerprint

Olfactory Bulb
Norepinephrine
Newborn Animals
Odorants
Locus Coeruleus
Signal-To-Noise Ratio
Adrenergic Receptors
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb. / Escanilla, Olga; Arrellanos, Adolfo; Karnow, Alexandra; Ennis, Matthew; Linster, Christiane.

In: European Journal of Neuroscience, Vol. 32, No. 3, 01.08.2010, p. 458-468.

Research output: Contribution to journalArticle

Escanilla, Olga ; Arrellanos, Adolfo ; Karnow, Alexandra ; Ennis, Matthew ; Linster, Christiane. / Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb. In: European Journal of Neuroscience. 2010 ; Vol. 32, No. 3. pp. 458-468.
@article{9f67a74e05364d4dbadc2493de9518b5,
title = "Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb",
abstract = "The mammalian main olfactory bulb (MOB) receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in the acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor-dependent behaviors. Thus far, the role of NE in odor processing in adult rats remains less studied. We investigated the role of noradrenergic modulation in the MOB on odor detection and discrimination thresholds using behavioral and computational modeling approaches. Adult rats received bilateral MOB injections of vehicle, NE (0.1-1000 μm), noradrenergic receptor antagonists and NE + receptor antagonists combined. NE infusion improved odor detection and discrimination as a function of NE and odor concentration. The effect of NE on detection and discrimination magnitude at any given odor concentration varied in a non-linear function with respect to NE concentration. Receptor antagonist infusion demonstrated that α1 receptor activation is necessary for the modulatory effect of NE. Computational modeling showed that increases in the strength of α1 receptor activation leads to improved odor signal-to-noise ratio and spike synchronization in mitral cells that may underlie the behaviorally observed decrease of detection and discrimination thresholds. Our results are the first to show that direct infusion of NE or noradrenergic receptor antagonists into a primary sensory network modulates sensory detection and discrimination thresholds at very low stimulus concentrations.",
author = "Olga Escanilla and Adolfo Arrellanos and Alexandra Karnow and Matthew Ennis and Christiane Linster",
year = "2010",
month = "8",
day = "1",
doi = "10.1111/j.1460-9568.2010.07297.x",
language = "English (US)",
volume = "32",
pages = "458--468",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Noradrenergic modulation of behavioral odor detection and discrimination thresholds in the olfactory bulb

AU - Escanilla, Olga

AU - Arrellanos, Adolfo

AU - Karnow, Alexandra

AU - Ennis, Matthew

AU - Linster, Christiane

PY - 2010/8/1

Y1 - 2010/8/1

N2 - The mammalian main olfactory bulb (MOB) receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in the acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor-dependent behaviors. Thus far, the role of NE in odor processing in adult rats remains less studied. We investigated the role of noradrenergic modulation in the MOB on odor detection and discrimination thresholds using behavioral and computational modeling approaches. Adult rats received bilateral MOB injections of vehicle, NE (0.1-1000 μm), noradrenergic receptor antagonists and NE + receptor antagonists combined. NE infusion improved odor detection and discrimination as a function of NE and odor concentration. The effect of NE on detection and discrimination magnitude at any given odor concentration varied in a non-linear function with respect to NE concentration. Receptor antagonist infusion demonstrated that α1 receptor activation is necessary for the modulatory effect of NE. Computational modeling showed that increases in the strength of α1 receptor activation leads to improved odor signal-to-noise ratio and spike synchronization in mitral cells that may underlie the behaviorally observed decrease of detection and discrimination thresholds. Our results are the first to show that direct infusion of NE or noradrenergic receptor antagonists into a primary sensory network modulates sensory detection and discrimination thresholds at very low stimulus concentrations.

AB - The mammalian main olfactory bulb (MOB) receives a significant noradrenergic input from the locus coeruleus. Norepinephrine (NE) is involved in the acquisition of conditioned odor preferences in neonatal animals and in some species-specific odor-dependent behaviors. Thus far, the role of NE in odor processing in adult rats remains less studied. We investigated the role of noradrenergic modulation in the MOB on odor detection and discrimination thresholds using behavioral and computational modeling approaches. Adult rats received bilateral MOB injections of vehicle, NE (0.1-1000 μm), noradrenergic receptor antagonists and NE + receptor antagonists combined. NE infusion improved odor detection and discrimination as a function of NE and odor concentration. The effect of NE on detection and discrimination magnitude at any given odor concentration varied in a non-linear function with respect to NE concentration. Receptor antagonist infusion demonstrated that α1 receptor activation is necessary for the modulatory effect of NE. Computational modeling showed that increases in the strength of α1 receptor activation leads to improved odor signal-to-noise ratio and spike synchronization in mitral cells that may underlie the behaviorally observed decrease of detection and discrimination thresholds. Our results are the first to show that direct infusion of NE or noradrenergic receptor antagonists into a primary sensory network modulates sensory detection and discrimination thresholds at very low stimulus concentrations.

UR - http://www.scopus.com/inward/record.url?scp=77955157061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955157061&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2010.07297.x

DO - 10.1111/j.1460-9568.2010.07297.x

M3 - Article

VL - 32

SP - 458

EP - 468

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 3

ER -