Noradrenergic receptor mechanisms in neophobia

Jeffery Steketee, Peter B. Silverman, Alan C. Swann

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have previously demonstrated that depletion of forebrain norepinephrine (NE) led to an attenuation of neophobia in a novel environment, as defined by a greater preference for novel food over familiar food. To study further the role of forebrain NE in neophobia we chronically infused noradrenergic receptor ligands or forskolin into the lateral ventricles of sham and 6-hydroxydopamine dorsal bundle lesioned rats. Chronic NE infusions into lesioned animals reversed the lesion-induced shift in relative food preference. The beta receptor agonist isoproterenol had moderate effects similar to those of NE in lesioned and sham animals. Phenylephrine, an alpha-1 agonist, was without effect. Forskolin, an adenylate cyclase activator, mimicked the effects of NE infusions. These data suggest a role for noradrenergic stimulation of adenylate cyclase in neophobia.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalPsychopharmacology
Volume106
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Norepinephrine
Food Preferences
Colforsin
Prosencephalon
Adenylyl Cyclases
Lateral Ventricles
Oxidopamine
Phenylephrine
Isoproterenol
Ligands
Food

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Noradrenergic receptor mechanisms in neophobia. / Steketee, Jeffery; Silverman, Peter B.; Swann, Alan C.

In: Psychopharmacology, Vol. 106, No. 1, 01.01.1992, p. 136-142.

Research output: Contribution to journalArticle

Steketee, Jeffery ; Silverman, Peter B. ; Swann, Alan C. / Noradrenergic receptor mechanisms in neophobia. In: Psychopharmacology. 1992 ; Vol. 106, No. 1. pp. 136-142.
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