Normal quantity and distribution of mast cells and eosinophils in the pediatric colon

Research output: Contribution to journalArticle

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Abstract

The normal number and distribution of mast cells (MCs) and eosinophils in colonic mucosa are largely unknown. Accordingly, we examined colonic biopsies obtained during endoscopic examinations of pediatric patients. The study included 41 patients (21 males and 20 females). The mean age was 11.72 years (range 3.3-19.7 years). Patients were followed for a mean time of 23.4 months (range 12-50 months). Our results showed a gradual decrease in the number of eosinophils in the lamina propria from the cecum to the descending colon (14.2 ± 6.1 and 10.7 ± 5.6 eosinophils//high-power field [hpf], respectively), with another peak in the rectosigmoid (12.4 ± 6.1 eosinophils/hpf). Eosinophils within the surface and crypt epithelium were more commonly encountered in the cecum and the rectosigmoid. Eosinophils clusters were rare but were more frequently found in the cecum and rectosigmoid. The largest number of MCs was observed in the descending colon and the lowest in the rectosigmoid (17.56 ± 7.28 and 14.5 ± 6.35 MCs/hpf, respectively). No MCs were identified within the surface epithelium. Very rare MCs were observed within the crypt epithelium, with the highest number observed in the cecum (0.34 ± 0.53 MCs/hpf) and the lowest number observed in the descending colon (0.02 ± 0.16 MCs/hpf). More MCs were present in the cecum and descending colon of females vs males (P = 0.02 and 0.04, respectively). Our results establish baseline gastrointestinal eosinophils and MC counts in various parts of the pediatric colon.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalPediatric and Developmental Pathology
Volume14
Issue number4
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

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Normal Distribution
Eosinophils
Mast Cells
Colon
Pediatrics
Cecum
Descending Colon
Epithelium
Mucous Membrane
Cell Count
Biopsy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Normal quantity and distribution of mast cells and eosinophils in the pediatric colon. / Saad, Ali.

In: Pediatric and Developmental Pathology, Vol. 14, No. 4, 01.07.2011, p. 294-300.

Research output: Contribution to journalArticle

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