Normal thoracic and abdominal distribution of 2-deoxy-2-[ 18f]fluoro-d-glucose ( 18fdg) in adult cats

Amy K. Leblanc, Jonathan Wall, Federica Morandi, Stephen Kennel, Alan Stuckey, Bjoern Jakoby, David W. Townsend, Gregory B. Daniel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-d-glucose (18FDG) is an important imaging modality for diagnosis and staging of human neoplastic disease. The purpose of this study is to describe the normal 18FDG uptake in adult cats. Six adult healthy female cats were used. Cats were sedated and then injected intravenously with 74.0±13.0 (mean±SD) MBq of 18FDG. General anesthesia was induced and cats were placed in ventral recumbancy on the PET scanner's bed. Static images using multiple bed positions were acquired approximately 60-90 min after injection. A transmission scan was acquired at each bed position utilizing a 57Co point source to perform attenuation and scatter correction. Regions of interest (ROIs) were drawn over the liver, right and left renal cortices, left ventricular wall, and wall of ascending and descending colonic segments. Standardized uptake values (SUV) were calculated using an established formula. Kidneys and intestinal tract had relatively intense uptake of 18FDG; liver activity was intermediate; the spleen was not identified in any of the cats. Cardiac activity was variable but intense activity was noted in the left ventricular myocardium in most cats. No appreciable lung uptake was noted. Mean±SD SUV values were calculated. This study established the normal pattern of uptake of 18FDG in adult cats and provided baseline data for comparison with future studies evaluating a variety of neoplastic and nonneoplastic diseases.

Original languageEnglish (US)
Pages (from-to)436-441
Number of pages6
JournalVeterinary Radiology and Ultrasound
Volume50
Issue number4
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

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chest
Cats
Thorax
cats
Glucose
glucose
uptake mechanisms
positron-emission tomography
Positron-Emission Tomography
kidneys
Kidney
liver
Liver
scanners
myocardium
General Anesthesia
Myocardium
anesthesia
cortex
spleen

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Normal thoracic and abdominal distribution of 2-deoxy-2-[ 18f]fluoro-d-glucose ( 18fdg) in adult cats. / Leblanc, Amy K.; Wall, Jonathan; Morandi, Federica; Kennel, Stephen; Stuckey, Alan; Jakoby, Bjoern; Townsend, David W.; Daniel, Gregory B.

In: Veterinary Radiology and Ultrasound, Vol. 50, No. 4, 01.07.2009, p. 436-441.

Research output: Contribution to journalArticle

Leblanc, Amy K. ; Wall, Jonathan ; Morandi, Federica ; Kennel, Stephen ; Stuckey, Alan ; Jakoby, Bjoern ; Townsend, David W. ; Daniel, Gregory B. / Normal thoracic and abdominal distribution of 2-deoxy-2-[ 18f]fluoro-d-glucose ( 18fdg) in adult cats. In: Veterinary Radiology and Ultrasound. 2009 ; Vol. 50, No. 4. pp. 436-441.
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