Normothermic ex vivo liver perfusion

platform for liver graft assessment and therapeutic modification

Corey Eymard, James Markmann

Research output: Contribution to journalReview article

Abstract

Liver transplantation as a treatment for end stage liver failure remains limited in the United States by the number and quality of donor allografts. Static cold storage, the current standard of care for organ storage prior to transplantation, offers no method for assessment or therapeutic modification. Cold ischemia and its attendant hypoxia deplete cellular adenosine triphosphate (ATP) stores, promote cellular damage, and degrade overall organ quality. Normothermic ex vivo liver perfusion (NEVLP) offers the potential for assessment of allograft function and restoration of intracellular energy stores prior to transplantation. A completed phase III randomized trial demonstrated livers undergoing NEVLP prior to transplantation demonstrate superior early graft function and less early graft dysfunction. NEVLP offers a platform for modification of the allograft via the application of defatting or therapeutic cocktails, missense RNA technology, or gene editing modalities. The wide versatility of NEVLP appears to be a promising tool to expand the current pool of transplantable liver allografts.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalOrganogenesis
Volume14
Issue number4
DOIs
StatePublished - Oct 2 2018

Fingerprint

Grafts
Liver
Perfusion
Transplants
Allografts
Transplantation
Transplantation (surgical)
Therapeutics
RNA Editing
Cold Ischemia
Cell Hypoxia
Liver Failure
Standard of Care
Cold storage
Liver Transplantation
Adenosine Triphosphate
RNA
Restoration
Technology
Genes

All Science Journal Classification (ASJC) codes

  • Embryology
  • Biomedical Engineering
  • Developmental Biology
  • Transplantation

Cite this

Normothermic ex vivo liver perfusion : platform for liver graft assessment and therapeutic modification. / Eymard, Corey; Markmann, James.

In: Organogenesis, Vol. 14, No. 4, 02.10.2018, p. 169-171.

Research output: Contribution to journalReview article

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