Nosocomial sinusitis in patients in the medical intensive care unit

A prospective epidemiological study

David L. George, Pamela S. Falk, Gianfranco Meduri, Kenneth V. Leeper, Richard G. Wunderink, Elaine L. Steere, F. Kent Nunnally, Neal Beckford, C. Glen Mayhall

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

A prospective observational cohort study of nosocomial sinusitis was carried out in two medical intensive care units. Sinusitis was diagnosed by computed tomographic scanning and the culture of sinus fluid obtained by puncture of a maxillary sinus. Clinical and epidemiological data were collected at the time of admission to the unit and daily thereafter. Specimens from the nares, oropharynx, trachea, and stomach were cultured on admission and daily thereafter. The cumulative incidence of nosocomial sinusitis was 7.7%, and the incidence rates were 12 cases per 1,000 patient- days and 19.8 cases per 1,000 nasoenteric tube-days. Risk factors for nosocomial sinusitis, as determined by multiple logistic regression analysis, included nasal colonization with enteric gram-negative bacilli (odds ratio [OR], 6.4; 95% confidence interval [95% CI], 2.2-18.8; P = .007), feeding via nasoenteric tube (OR, 14.1; 95% CI, 1.7-117.6; P = .015), sedation (OR, 15.9; 95% CI, 1.9133.5; P = .011), and a Glasgow coma score of ≤7 (OR, 9.1; 95% CI, 3.0-27.3; P = .0001).

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalClinical Infectious Diseases
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1998

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Sinusitis
Intensive Care Units
Epidemiologic Studies
Odds Ratio
Prospective Studies
Confidence Intervals
Oropharynx
Maxillary Sinus
Incidence
Coma
Trachea
Nose
Punctures
Bacillus
Observational Studies
Stomach
Cohort Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

George, D. L., Falk, P. S., Meduri, G., Leeper, K. V., Wunderink, R. G., Steere, E. L., ... Mayhall, C. G. (1998). Nosocomial sinusitis in patients in the medical intensive care unit: A prospective epidemiological study. Clinical Infectious Diseases, 27(3), 463-470. https://doi.org/10.1086/514711

Nosocomial sinusitis in patients in the medical intensive care unit : A prospective epidemiological study. / George, David L.; Falk, Pamela S.; Meduri, Gianfranco; Leeper, Kenneth V.; Wunderink, Richard G.; Steere, Elaine L.; Nunnally, F. Kent; Beckford, Neal; Mayhall, C. Glen.

In: Clinical Infectious Diseases, Vol. 27, No. 3, 01.01.1998, p. 463-470.

Research output: Contribution to journalArticle

George, DL, Falk, PS, Meduri, G, Leeper, KV, Wunderink, RG, Steere, EL, Nunnally, FK, Beckford, N & Mayhall, CG 1998, 'Nosocomial sinusitis in patients in the medical intensive care unit: A prospective epidemiological study', Clinical Infectious Diseases, vol. 27, no. 3, pp. 463-470. https://doi.org/10.1086/514711
George, David L. ; Falk, Pamela S. ; Meduri, Gianfranco ; Leeper, Kenneth V. ; Wunderink, Richard G. ; Steere, Elaine L. ; Nunnally, F. Kent ; Beckford, Neal ; Mayhall, C. Glen. / Nosocomial sinusitis in patients in the medical intensive care unit : A prospective epidemiological study. In: Clinical Infectious Diseases. 1998 ; Vol. 27, No. 3. pp. 463-470.
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