Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists

Tao Bin, Tien L. Huang, Terre A. Sharma, Ian J. Reynolds, Isaac Donkor

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of novel bisbenzamidines and bisbenzimidazolines with different linkers connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC 50 values for these compounds ranged from 1.2 to >200 μM. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pentamidine analogues tested so far.

Original languageEnglish (US)
Pages (from-to)1299-1304
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number9
DOIs
StatePublished - May 3 1999

Fingerprint

N-Methyl-D-Aspartate Receptors
Pentamidine
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists. / Bin, Tao; Huang, Tien L.; Sharma, Terre A.; Reynolds, Ian J.; Donkor, Isaac.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 9, 03.05.1999, p. 1299-1304.

Research output: Contribution to journalArticle

Bin, Tao ; Huang, Tien L. ; Sharma, Terre A. ; Reynolds, Ian J. ; Donkor, Isaac. / Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 9. pp. 1299-1304.
@article{bfe2bd9aea544f4e814c5a48199ebe33,
title = "Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists",
abstract = "A series of novel bisbenzamidines and bisbenzimidazolines with different linkers connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC 50 values for these compounds ranged from 1.2 to >200 μM. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pentamidine analogues tested so far.",
author = "Tao Bin and Huang, {Tien L.} and Sharma, {Terre A.} and Reynolds, {Ian J.} and Isaac Donkor",
year = "1999",
month = "5",
day = "3",
doi = "10.1016/S0960-894X(99)00184-5",
language = "English (US)",
volume = "9",
pages = "1299--1304",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists

AU - Bin, Tao

AU - Huang, Tien L.

AU - Sharma, Terre A.

AU - Reynolds, Ian J.

AU - Donkor, Isaac

PY - 1999/5/3

Y1 - 1999/5/3

N2 - A series of novel bisbenzamidines and bisbenzimidazolines with different linkers connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC 50 values for these compounds ranged from 1.2 to >200 μM. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pentamidine analogues tested so far.

AB - A series of novel bisbenzamidines and bisbenzimidazolines with different linkers connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC 50 values for these compounds ranged from 1.2 to >200 μM. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pentamidine analogues tested so far.

UR - http://www.scopus.com/inward/record.url?scp=0033519177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033519177&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(99)00184-5

DO - 10.1016/S0960-894X(99)00184-5

M3 - Article

VL - 9

SP - 1299

EP - 1304

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 9

ER -