Novel bone endocrine networks integrating mineral and energy metabolism

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The skeleton is an endocrine organ that regulates energy metabolism through the release of the osteoblast-derived hormone, osteocalcin (Ocn), and phosphate and vitamin D homeostasis through the secretion by osteoblasts and osteocytes of the novel hormone, FGF23 Ocn activates a widely expressed G-protein coupled receptor, GPRC6A, to regulate insulin secretion by pancreatic β-cells, testosterone secretion by testicular Leydig cells, fatty acid metabolism in the liver, and insulin sensitivity of muscle and fat, as well as other functions. FGF23 targets a limited number of tissues, including kidney, parathyroid gland, choroid plexus, and pituitary gland that co-express FGF receptors and α-Klotho complexes. Ectodomain shedding and secretion of a soluble form of Klotho also is purported to act as an anti-ageing hormone. Further elucidation of these novel endocrine networks is likely to lead to new appreciation of the cooperation between various organ systems to regulate phosphate, vitamin D, and energy metabolism.

Original languageEnglish (US)
Pages (from-to)391-399
Number of pages9
JournalCurrent Osteoporosis Reports
Volume11
Issue number4
DOIs
StatePublished - Dec 1 2013

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Energy Metabolism
Minerals
Osteocalcin
Hormones
Osteoblasts
Bone and Bones
Vitamin D
Phosphates
Osteocytes
Fibroblast Growth Factor Receptors
Choroid Plexus
Parathyroid Glands
Leydig Cells
Pituitary Gland
G-Protein-Coupled Receptors
Skeleton
Insulin Resistance
Testosterone
Homeostasis
Fatty Acids

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Novel bone endocrine networks integrating mineral and energy metabolism. / Pi, Min; Quarles, Leigh.

In: Current Osteoporosis Reports, Vol. 11, No. 4, 01.12.2013, p. 391-399.

Research output: Contribution to journalArticle

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