Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method

Wan Qiang Lv, Xue Zhang, Qiang Zhang, Jing Yang He, Hui Min Liu, Xin Xia, Kun Fan, Qi Zhao, Xue Zhong Shi, Wei Dong Zhang, Chang Qing Sun, Hong Wen Deng

Research output: Contribution to journalArticle

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Abstract

Genome-wide association studies (GWAS) have been successfully applied in identifying single nucleotide polymorphisms (SNPs) associated with body mass index (BMI) and coronary heart disease (CAD). However, the SNPs to date can only explain a small percentage of the genetic variances of traits. Here, we applied a genetic pleiotropic conditional false discovery rate (cFDR) method that combines summary statistic p values from different multi-center GWAS datasets, to detect common genetic variants associated with these two traits. The enrichment of SNPs associated with BMI and CAD was assessed by conditional Q-Q plots and the common variants were identified by the cFDR method. By applying the cFDR level of 0.05, 7 variants were identified to be associated with CAD (2 variants being novel), 34 variants associated with BMI (11 variants being novel), and 3 variants associated with both BMI and CAD (2 variants being novel). The SNP rs653178 (ATXN2) is noteworthy as this variant was replicated in an independent analysis. SNP rs12411886 (CNNM2) and rs794356 (HIP1) were of note as the annotated genes may be associated with processes that are functionally important in lipid metabolism. In conclusion, the cFDR method identified novel variants associated with BMI and/or CAD by effectively incorporating different GWAS datasets.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Molecular and Cellular Cardiology
Volume112
DOIs
StatePublished - Nov 1 2017

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Single Nucleotide Polymorphism
Coronary Disease
Coronary Artery Disease
Body Mass Index
Genome-Wide Association Study
Lipid Metabolism
Genes
Datasets

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method. / Lv, Wan Qiang; Zhang, Xue; Zhang, Qiang; He, Jing Yang; Liu, Hui Min; Xia, Xin; Fan, Kun; Zhao, Qi; Shi, Xue Zhong; Zhang, Wei Dong; Sun, Chang Qing; Deng, Hong Wen.

In: Journal of Molecular and Cellular Cardiology, Vol. 112, 01.11.2017, p. 1-7.

Research output: Contribution to journalArticle

Lv, Wan Qiang ; Zhang, Xue ; Zhang, Qiang ; He, Jing Yang ; Liu, Hui Min ; Xia, Xin ; Fan, Kun ; Zhao, Qi ; Shi, Xue Zhong ; Zhang, Wei Dong ; Sun, Chang Qing ; Deng, Hong Wen. / Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method. In: Journal of Molecular and Cellular Cardiology. 2017 ; Vol. 112. pp. 1-7.
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AU - Xia, Xin

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AU - Zhao, Qi

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