Novel nanogels with both thermoresponsive and hydrolytically degradable properties

Xiao Huang, Gauri P. Misra, Amit Vaish, John M. Flanagan, Bryan Sutermaster, Tao Lowe

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A series of novel nanogels with both thermoresponsive and hydrolytically degradable properties were synthesized by emulsion polymerization of N-isopropylacrylamide (NIPAAm) and dextran-lactate-2-hydroxyethyl methacrylate (DEXlactateHEMA), a hydrolytically degradable and cross-linkable dextran derivative, without using low molar mass surfactants. Various lengths of degradable oligolactate units and different precursor feeding ratios between NIPAAm and DEXlactateHEMA were used to synthesize the nanogels. FTIR measurements confirmed the chemical compositions and hydrolytic degradation of the synthesized nanogels. Dynamic light scattering measurements of the hydrodynamic radii of the nanogels in phosphate buffer saline (PBS, pH 7.4) against temperature and angle revealed that the nanogels were thermoresponsive with a lower critical solution temperature (LCST) of ∼32 °C. The size and morphology changes of the nanogels with degradation were investigated by using transmission electron microscopy, atomic force microscopy, and static light scattering techniques. AFM image analysis and Holtzer plots revealed that the nanogels became more rigid with degradation in water solutions.

Original languageEnglish (US)
Pages (from-to)8339-8345
Number of pages7
JournalMacromolecules
Volume41
Issue number22
DOIs
StatePublished - Nov 25 2008
Externally publishedYes

Fingerprint

Dextran
Degradation
Dextrans
Molar mass
Emulsion polymerization
Dynamic light scattering
Light scattering
Image analysis
Atomic force microscopy
Phosphates
Surface active agents
Hydrodynamics
Lactic Acid
Transmission electron microscopy
Derivatives
Temperature
Chemical analysis
NanoGel
Water
Surface-Active Agents

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry

Cite this

Huang, X., Misra, G. P., Vaish, A., Flanagan, J. M., Sutermaster, B., & Lowe, T. (2008). Novel nanogels with both thermoresponsive and hydrolytically degradable properties. Macromolecules, 41(22), 8339-8345. https://doi.org/10.1021/ma800081g

Novel nanogels with both thermoresponsive and hydrolytically degradable properties. / Huang, Xiao; Misra, Gauri P.; Vaish, Amit; Flanagan, John M.; Sutermaster, Bryan; Lowe, Tao.

In: Macromolecules, Vol. 41, No. 22, 25.11.2008, p. 8339-8345.

Research output: Contribution to journalArticle

Huang, X, Misra, GP, Vaish, A, Flanagan, JM, Sutermaster, B & Lowe, T 2008, 'Novel nanogels with both thermoresponsive and hydrolytically degradable properties', Macromolecules, vol. 41, no. 22, pp. 8339-8345. https://doi.org/10.1021/ma800081g
Huang, Xiao ; Misra, Gauri P. ; Vaish, Amit ; Flanagan, John M. ; Sutermaster, Bryan ; Lowe, Tao. / Novel nanogels with both thermoresponsive and hydrolytically degradable properties. In: Macromolecules. 2008 ; Vol. 41, No. 22. pp. 8339-8345.
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