Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration

Ravisekhar Gadepalli, Sivareddy Kotla, Mark R. Heckle, Shailendra K. Verma, Nikhlesh Singh, Rao Gadiparthi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The major goal of this study is to test the hypothesis that thrombin plays a role in inflammation. Results: Thrombin stimulates monocyte F-actin cytoskeletal remodeling and migration by PAR1, G12, Pyk2, Gab1, Rac1, and RhoA-dependent Pak2 activation. Conclusion: Pak2 mediates thrombin-PAR1-induced monocyte/macrophage migration. Significance: PAR1 could be a potential target for the development of anti-inflammatory drugs.

Original languageEnglish (US)
Pages (from-to)30815-30831
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number43
DOIs
StatePublished - Oct 25 2013

Fingerprint

p21-Activated Kinases
Thrombin
Monocytes
Macrophages
Actins
Anti-Inflammatory Agents
Chemical activation
Inflammation
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. / Gadepalli, Ravisekhar; Kotla, Sivareddy; Heckle, Mark R.; Verma, Shailendra K.; Singh, Nikhlesh; Gadiparthi, Rao.

In: Journal of Biological Chemistry, Vol. 288, No. 43, 25.10.2013, p. 30815-30831.

Research output: Contribution to journalArticle

Gadepalli, Ravisekhar ; Kotla, Sivareddy ; Heckle, Mark R. ; Verma, Shailendra K. ; Singh, Nikhlesh ; Gadiparthi, Rao. / Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 43. pp. 30815-30831.
@article{fccf49df723c43e49def4cc195573503,
title = "Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration",
abstract = "Background: The major goal of this study is to test the hypothesis that thrombin plays a role in inflammation. Results: Thrombin stimulates monocyte F-actin cytoskeletal remodeling and migration by PAR1, G12, Pyk2, Gab1, Rac1, and RhoA-dependent Pak2 activation. Conclusion: Pak2 mediates thrombin-PAR1-induced monocyte/macrophage migration. Significance: PAR1 could be a potential target for the development of anti-inflammatory drugs.",
author = "Ravisekhar Gadepalli and Sivareddy Kotla and Heckle, {Mark R.} and Verma, {Shailendra K.} and Nikhlesh Singh and Rao Gadiparthi",
year = "2013",
month = "10",
day = "25",
doi = "10.1074/jbc.M113.463414",
language = "English (US)",
volume = "288",
pages = "30815--30831",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "43",

}

TY - JOUR

T1 - Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration

AU - Gadepalli, Ravisekhar

AU - Kotla, Sivareddy

AU - Heckle, Mark R.

AU - Verma, Shailendra K.

AU - Singh, Nikhlesh

AU - Gadiparthi, Rao

PY - 2013/10/25

Y1 - 2013/10/25

N2 - Background: The major goal of this study is to test the hypothesis that thrombin plays a role in inflammation. Results: Thrombin stimulates monocyte F-actin cytoskeletal remodeling and migration by PAR1, G12, Pyk2, Gab1, Rac1, and RhoA-dependent Pak2 activation. Conclusion: Pak2 mediates thrombin-PAR1-induced monocyte/macrophage migration. Significance: PAR1 could be a potential target for the development of anti-inflammatory drugs.

AB - Background: The major goal of this study is to test the hypothesis that thrombin plays a role in inflammation. Results: Thrombin stimulates monocyte F-actin cytoskeletal remodeling and migration by PAR1, G12, Pyk2, Gab1, Rac1, and RhoA-dependent Pak2 activation. Conclusion: Pak2 mediates thrombin-PAR1-induced monocyte/macrophage migration. Significance: PAR1 could be a potential target for the development of anti-inflammatory drugs.

UR - http://www.scopus.com/inward/record.url?scp=84886680226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886680226&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.463414

DO - 10.1074/jbc.M113.463414

M3 - Article

VL - 288

SP - 30815

EP - 30831

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 43

ER -