Nuclear apoptosis contributes to sarcopenia

Stephen Alway, Parco M. Siu

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalExercise and sport sciences reviews
Volume36
Issue number2
DOIs
StatePublished - Apr 1 2008

Fingerprint

Sarcopenia
Apoptosis
DNA Fragmentation
Atrophy
Muscles

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Nuclear apoptosis contributes to sarcopenia. / Alway, Stephen; Siu, Parco M.

In: Exercise and sport sciences reviews, Vol. 36, No. 2, 01.04.2008, p. 51-57.

Research output: Contribution to journalReview article

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