Nucleolar stress characterized by downregulation of nucleophosmin

A novel cause of neuronal degeneration

Esther Marquez-Lona, Zhiqun Tan, Steven S. Schreiber

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Nucleophosmin (NPM) is a multifunctional nucleolar protein that has been linked with nucleolar stress. In non-neuronal cell lines, NPM may enhance or inhibit the activity of tumor suppressor p53, a major apoptotic protein. The relationship between NPM and p53 in the central nervous system (CNS) remains unknown. Here, we assessed the role of NPM in the CNS using a model of seizure-induced neurodegeneration. We show that NPM overexpression is neuroprotective against kainic acid-induced excitotoxicity, and that downregulation of NPM is pro-apoptotic in a p53-independent manner. These results suggest a key role for NPM in promoting neuronal survival and a novel mechanism of neuronal degeneration triggered by nucleolar stress.

Original languageEnglish (US)
Pages (from-to)514-520
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume417
Issue number1
DOIs
StatePublished - Jan 6 2012

Fingerprint

Down-Regulation
Neurology
Central Nervous System
Kainic Acid
Nuclear Proteins
nucleophosmin
Tumors
Seizures
Cells
Cell Line
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Nucleolar stress characterized by downregulation of nucleophosmin : A novel cause of neuronal degeneration. / Marquez-Lona, Esther; Tan, Zhiqun; Schreiber, Steven S.

In: Biochemical and Biophysical Research Communications, Vol. 417, No. 1, 06.01.2012, p. 514-520.

Research output: Contribution to journalArticle

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