Nutrient dyshomeostasis in congestive heart failure

German Kamalov, Joshua P. Holewinski, Syamal Bhattacharya, Robert A. Ahokas, Yao Sun, Ivan Gerling, Karl Weber

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The clinical syndrome congestive heart failure (CHF) has its origins rooted in a salt-avid state mediated largely by effector hormones of the renin-angiotensin-aldosterone system. In recent years, this cardiorenal perspective of CHF has taken on a broader perspective. One which focuses on a progressive systemic illness, whose major features include the presence of oxidative stress in diverse tissues and elevated circulating levels of proinflammatory cytokines coupled with a wasting of soft tissues and bone. Experimental studies, which simulate chronic renin-angiotensin-aldosterone system activation, and translational studies in patients with salt avidity having decompensated biventricular failure with hepatic and splanchnic congestion have forged a broader understanding of this illness and the important contribution of a dyshomeostasis of Ca, Mg, Zn, Se, and vitamins D, B12, and B1. Herein, we review biomarkers indicative of the nutrient imbalance found in CHF and raise the question of a need for a polynutrient supplement in the overall management of CHF.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume338
Issue number1
DOIs
StatePublished - Jan 1 2009

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Heart Failure
Food
Renin-Angiotensin System
Salts
Viscera
Thiamine
Liver Failure
Vitamin B 12
Vitamin D
Oxidative Stress
Biomarkers
Hormones
Cytokines
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Nutrient dyshomeostasis in congestive heart failure. / Kamalov, German; Holewinski, Joshua P.; Bhattacharya, Syamal; Ahokas, Robert A.; Sun, Yao; Gerling, Ivan; Weber, Karl.

In: American Journal of the Medical Sciences, Vol. 338, No. 1, 01.01.2009, p. 28-33.

Research output: Contribution to journalArticle

Kamalov, German ; Holewinski, Joshua P. ; Bhattacharya, Syamal ; Ahokas, Robert A. ; Sun, Yao ; Gerling, Ivan ; Weber, Karl. / Nutrient dyshomeostasis in congestive heart failure. In: American Journal of the Medical Sciences. 2009 ; Vol. 338, No. 1. pp. 28-33.
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