Nutritional intake of long-term survivors of childhood acute lymphoblastic leukemia

Evidence for bone health interventional opportunities

Frances Tylavsky, Karen Smith, Harriet Surprise, Sarah Garland, Xiaowei Yan, Elizabeth McCammon, Melissa M. Hudson, Ching Hon Pui, Sue C. Kaste

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Survivors of childhood acute lymphoblastic leukemia (ALL) are vulnerable to exaggeration of the aging process including decreased bone mineral density (BMD). As little is known about their dietary or nutrient intake that may affect their long-term bone health, we examined nutrient intake in long-term survivors of childhood ALL. Procedure: Survivors (n=164) of childhood ALL who had completed treatment for at least 5 years and were in continuous remission, completed a 110-item food questionnaire that reflected dietary intake over the previous year. The analyzed cohort comprised 34 females and 38 males younger than 19 years and 45 females and 47 males at least 19 years. Reported nutrient intake and food selection were compared with age-specific Recommended Dietary Allowance and USDA Pyramid Food Guide. Body mass index was compared to the general US population, adjusted for age, gender, Tanner stage and race. Results: Less than 30% of participants met recommended dietary intakes for vitamin D, calcium, potassium, or magnesium regardless of age. Mean daily caloric intake was 2,204kcal (51% from carbohydrates) for younger and 2,160kcal (49% from carbohydrates) for older participants. Energy intake from sweets was 70% higher than recommended. Participants <19 years were less likely to have a healthy weight (odds ratio 0.48, 95% CI 0.30-0.79); >19 years more likely to be overweight (odds ratio 1.95, 95% CI 1.11-3.32, P<0.002). Conclusions: Survivors of childhood ALL need careful dietary intervention to optimize long-term health.

Original languageEnglish (US)
Pages (from-to)1362-1369
Number of pages8
JournalPediatric Blood and Cancer
Volume55
Issue number7
DOIs
StatePublished - Dec 1 2010

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survivors
Bone and Bones
Food
Health
Energy Intake
Carbohydrates
Food Preferences
Recommended Dietary Allowances
United States Department of Agriculture
Vitamin D
Bone Density
Magnesium
Potassium
Body Mass Index
Odds Ratio
Calcium
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Nutritional intake of long-term survivors of childhood acute lymphoblastic leukemia : Evidence for bone health interventional opportunities. / Tylavsky, Frances; Smith, Karen; Surprise, Harriet; Garland, Sarah; Yan, Xiaowei; McCammon, Elizabeth; Hudson, Melissa M.; Pui, Ching Hon; Kaste, Sue C.

In: Pediatric Blood and Cancer, Vol. 55, No. 7, 01.12.2010, p. 1362-1369.

Research output: Contribution to journalArticle

Tylavsky, Frances ; Smith, Karen ; Surprise, Harriet ; Garland, Sarah ; Yan, Xiaowei ; McCammon, Elizabeth ; Hudson, Melissa M. ; Pui, Ching Hon ; Kaste, Sue C. / Nutritional intake of long-term survivors of childhood acute lymphoblastic leukemia : Evidence for bone health interventional opportunities. In: Pediatric Blood and Cancer. 2010 ; Vol. 55, No. 7. pp. 1362-1369.
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abstract = "Background: Survivors of childhood acute lymphoblastic leukemia (ALL) are vulnerable to exaggeration of the aging process including decreased bone mineral density (BMD). As little is known about their dietary or nutrient intake that may affect their long-term bone health, we examined nutrient intake in long-term survivors of childhood ALL. Procedure: Survivors (n=164) of childhood ALL who had completed treatment for at least 5 years and were in continuous remission, completed a 110-item food questionnaire that reflected dietary intake over the previous year. The analyzed cohort comprised 34 females and 38 males younger than 19 years and 45 females and 47 males at least 19 years. Reported nutrient intake and food selection were compared with age-specific Recommended Dietary Allowance and USDA Pyramid Food Guide. Body mass index was compared to the general US population, adjusted for age, gender, Tanner stage and race. Results: Less than 30{\%} of participants met recommended dietary intakes for vitamin D, calcium, potassium, or magnesium regardless of age. Mean daily caloric intake was 2,204kcal (51{\%} from carbohydrates) for younger and 2,160kcal (49{\%} from carbohydrates) for older participants. Energy intake from sweets was 70{\%} higher than recommended. Participants <19 years were less likely to have a healthy weight (odds ratio 0.48, 95{\%} CI 0.30-0.79); >19 years more likely to be overweight (odds ratio 1.95, 95{\%} CI 1.11-3.32, P<0.002). Conclusions: Survivors of childhood ALL need careful dietary intervention to optimize long-term health.",
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AU - Yan, Xiaowei

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AU - Hudson, Melissa M.

AU - Pui, Ching Hon

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