Obesity and endothelial dysfunction

Sudha S. Shankar, Helmut Steinberg

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Obesity is becoming more prevalent in the developed world because of the abundance of food and the decrease of physical activity. Obesity is a risk factor for a host of diseases from arthritis to cardiovascular disease. The precise mechanisms by which obesity promotes cardiovascular disease are not well understood but are likely to include metabolic and inflammatory responses to the increased amount of stored fat. The endothelium plays a pivotal role in maintaining vascular health. Impaired endothelial function is an independent predictor of cardiovascular disease. Most studies of vascular function in obese subjects have demonstrated impaired endothelial function. This impairment of endothelial function becomes obvious early on, long before any vascular abnormalities become clinically relevant and detectable. Better understanding of the mediators of obesity-induced endothelial dysfunction may lead to the identification of new targets for interventions that may prevent or postpone the development of obesity-related cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalSeminars in Vascular Medicine
Volume5
Issue number1
DOIs
StatePublished - Jun 6 2005

Fingerprint

Obesity
Cardiovascular Diseases
Blood Vessels
Arthritis
Endothelium
Fats
Food
Health

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Obesity and endothelial dysfunction. / Shankar, Sudha S.; Steinberg, Helmut.

In: Seminars in Vascular Medicine, Vol. 5, No. 1, 06.06.2005, p. 56-64.

Research output: Contribution to journalReview article

Shankar, Sudha S. ; Steinberg, Helmut. / Obesity and endothelial dysfunction. In: Seminars in Vascular Medicine. 2005 ; Vol. 5, No. 1. pp. 56-64.
@article{9adddc00d4fd413e853b37d60ad3c4d1,
title = "Obesity and endothelial dysfunction",
abstract = "Obesity is becoming more prevalent in the developed world because of the abundance of food and the decrease of physical activity. Obesity is a risk factor for a host of diseases from arthritis to cardiovascular disease. The precise mechanisms by which obesity promotes cardiovascular disease are not well understood but are likely to include metabolic and inflammatory responses to the increased amount of stored fat. The endothelium plays a pivotal role in maintaining vascular health. Impaired endothelial function is an independent predictor of cardiovascular disease. Most studies of vascular function in obese subjects have demonstrated impaired endothelial function. This impairment of endothelial function becomes obvious early on, long before any vascular abnormalities become clinically relevant and detectable. Better understanding of the mediators of obesity-induced endothelial dysfunction may lead to the identification of new targets for interventions that may prevent or postpone the development of obesity-related cardiovascular disease.",
author = "Shankar, {Sudha S.} and Helmut Steinberg",
year = "2005",
month = "6",
day = "6",
doi = "10.1055/s-2005-871742",
language = "English (US)",
volume = "5",
pages = "56--64",
journal = "Seminars in Vascular Medicine",
issn = "1528-9648",
publisher = "Thieme Medical Publishers",
number = "1",

}

TY - JOUR

T1 - Obesity and endothelial dysfunction

AU - Shankar, Sudha S.

AU - Steinberg, Helmut

PY - 2005/6/6

Y1 - 2005/6/6

N2 - Obesity is becoming more prevalent in the developed world because of the abundance of food and the decrease of physical activity. Obesity is a risk factor for a host of diseases from arthritis to cardiovascular disease. The precise mechanisms by which obesity promotes cardiovascular disease are not well understood but are likely to include metabolic and inflammatory responses to the increased amount of stored fat. The endothelium plays a pivotal role in maintaining vascular health. Impaired endothelial function is an independent predictor of cardiovascular disease. Most studies of vascular function in obese subjects have demonstrated impaired endothelial function. This impairment of endothelial function becomes obvious early on, long before any vascular abnormalities become clinically relevant and detectable. Better understanding of the mediators of obesity-induced endothelial dysfunction may lead to the identification of new targets for interventions that may prevent or postpone the development of obesity-related cardiovascular disease.

AB - Obesity is becoming more prevalent in the developed world because of the abundance of food and the decrease of physical activity. Obesity is a risk factor for a host of diseases from arthritis to cardiovascular disease. The precise mechanisms by which obesity promotes cardiovascular disease are not well understood but are likely to include metabolic and inflammatory responses to the increased amount of stored fat. The endothelium plays a pivotal role in maintaining vascular health. Impaired endothelial function is an independent predictor of cardiovascular disease. Most studies of vascular function in obese subjects have demonstrated impaired endothelial function. This impairment of endothelial function becomes obvious early on, long before any vascular abnormalities become clinically relevant and detectable. Better understanding of the mediators of obesity-induced endothelial dysfunction may lead to the identification of new targets for interventions that may prevent or postpone the development of obesity-related cardiovascular disease.

UR - http://www.scopus.com/inward/record.url?scp=19344372150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19344372150&partnerID=8YFLogxK

U2 - 10.1055/s-2005-871742

DO - 10.1055/s-2005-871742

M3 - Review article

C2 - 15968581

AN - SCOPUS:19344372150

VL - 5

SP - 56

EP - 64

JO - Seminars in Vascular Medicine

JF - Seminars in Vascular Medicine

SN - 1528-9648

IS - 1

ER -