Obesity and hormone-dependent tumors: Cohort and co-twin control studies based on the Swedish Twin Registry

Fredrik Jonssoni, Alicja Wolk, Nancy L. Pedersen, Paul Lichtenstein, Paul Terry, Anders Ahlbom, Maria Feychting

Research output: Contribution to journalArticle

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Abstract

Obesity increases the risk of certain cancer types, e.g., cancer of the endometrium, colon and gallbladder. For some other cancer forms, e.g., prostate cancer, the association is less clear. We examined the association between body mass index (BMI) and hormone-dependent tumors, utilizing a cohort of 21,884 Swedish twins born during 1886-1925. Information about BMI at different ages and potential confounding factors was collected prospectively. The Swedish Cancer Registry was used to identify cases of cancer in the prostate (n = 666), breast (n = 607), corpus uteri (n = 150) and ovary (n = 118) during 1969-1997. The material was analyzed as a traditional cohort and with co-twin control analyses that allow for control of genetic influences. Obesity (BMI ≥30 kg/m2) at baseline was positively associated with cancer in the corpus uteri [relative risk (RR) = 3.03, 95% confidence interval (CI) 1.82-5.03], as was BMI at age 25, independently of BMI at baseline. Increased risk was also found for breast cancer but only in older women (≥70 years). Overweight at age 25 was associated with decreased risk of breast cancer (RR = 0.51, 95% Cl 0.33-0.78). No association was found for prostate cancer. We conclude that age is an important effect modifier of cancer risk associated with obesity and that obesity and overweight in young adult life may affect cancer risk also later in life.

Original languageEnglish (US)
Pages (from-to)594-599
Number of pages6
JournalInternational Journal of Cancer
Volume106
Issue number4
DOIs
StatePublished - Sep 10 2003
Externally publishedYes

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Twin Studies
Registries
Obesity
Hormones
Body Mass Index
Neoplasms
Prostatic Neoplasms
Uterus
Breast Neoplasms
Gallbladder Neoplasms
Endometrial Neoplasms
Colonic Neoplasms
Young Adult
Ovary
Breast
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Obesity and hormone-dependent tumors : Cohort and co-twin control studies based on the Swedish Twin Registry. / Jonssoni, Fredrik; Wolk, Alicja; Pedersen, Nancy L.; Lichtenstein, Paul; Terry, Paul; Ahlbom, Anders; Feychting, Maria.

In: International Journal of Cancer, Vol. 106, No. 4, 10.09.2003, p. 594-599.

Research output: Contribution to journalArticle

Jonssoni, Fredrik ; Wolk, Alicja ; Pedersen, Nancy L. ; Lichtenstein, Paul ; Terry, Paul ; Ahlbom, Anders ; Feychting, Maria. / Obesity and hormone-dependent tumors : Cohort and co-twin control studies based on the Swedish Twin Registry. In: International Journal of Cancer. 2003 ; Vol. 106, No. 4. pp. 594-599.
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