Obesity, weight gain, and ovarian cancer risk in African American women

Elisa V. Bandera, Bo Qin, Patricia G. Moorman, Anthony J. Alberg, Jill S. Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Paul Terry, Joellen M. Schildkraut

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Abstract

Although there is growing evidence that higher adiposity increases ovarian cancer risk, little is known about its impact in African American (AA) women, the racial/ethnic group with the highest prevalence of obesity. We evaluated the impact of body mass index (BMI) 1 year before diagnosis and weight gain since age 18 years on ovarian cancer risk in a population-based case-control study in AA women in 11 geographical areas in the US. Cases (n = 492) and age and site matched controls (n = 696) were identified through rapid case ascertainment and random-digit-dialing, respectively. Information was collected on demographic and lifestyle factors, including self-reported height, weight at age 18 and weight 1 year before diagnosis/interview. Multivariable logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI), adjusting for potential covariates. Obese women had elevated ovarian cancer risk, particularly for BMI ≥ 40 kg/m2 compared to BMI <25 (OR = 1.72, 95% CI: 1.12-2.66; p for trend: 0.03). There was also a strong association with weight gain since age 18 (OR: 1.52; 95% CI: 1.07-2.16; p for trend: 0.02) comparing the highest to lowest quartile. In stratified analyses by menopausal status, the association with BMI and weight gain was limited to postmenopausal women, with a 15% (95% CI: 1.05-1.23) increase in risk per 5 kg/m2 of BMI and 6% (95% CI: 1.01-1.10) increase in risk per 5 kg of weight gain. Excluding hormone therapy users essentially did not change results. Obesity and excessive adult weight gain may increase ovarian cancer risk in post-menopausal AA women.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalInternational Journal of Cancer
Volume139
Issue number3
DOIs
StatePublished - Aug 1 2016

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African Americans
Ovarian Neoplasms
Weight Gain
Obesity
Body Mass Index
Confidence Intervals
Odds Ratio
Weights and Measures
Adiposity
Ethnic Groups
Case-Control Studies
Life Style
Logistic Models
Demography
Hormones
Interviews
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Bandera, E. V., Qin, B., Moorman, P. G., Alberg, A. J., Barnholtz-Sloan, J. S., Bondy, M., ... Schildkraut, J. M. (2016). Obesity, weight gain, and ovarian cancer risk in African American women. International Journal of Cancer, 139(3), 593-600. https://doi.org/10.1002/ijc.30115

Obesity, weight gain, and ovarian cancer risk in African American women. / Bandera, Elisa V.; Qin, Bo; Moorman, Patricia G.; Alberg, Anthony J.; Barnholtz-Sloan, Jill S.; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Terry, Paul; Schildkraut, Joellen M.

In: International Journal of Cancer, Vol. 139, No. 3, 01.08.2016, p. 593-600.

Research output: Contribution to journalArticle

Bandera, EV, Qin, B, Moorman, PG, Alberg, AJ, Barnholtz-Sloan, JS, Bondy, M, Cote, ML, Funkhouser, E, Peters, ES, Schwartz, AG, Terry, P & Schildkraut, JM 2016, 'Obesity, weight gain, and ovarian cancer risk in African American women', International Journal of Cancer, vol. 139, no. 3, pp. 593-600. https://doi.org/10.1002/ijc.30115
Bandera EV, Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M et al. Obesity, weight gain, and ovarian cancer risk in African American women. International Journal of Cancer. 2016 Aug 1;139(3):593-600. https://doi.org/10.1002/ijc.30115
Bandera, Elisa V. ; Qin, Bo ; Moorman, Patricia G. ; Alberg, Anthony J. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Terry, Paul ; Schildkraut, Joellen M. / Obesity, weight gain, and ovarian cancer risk in African American women. In: International Journal of Cancer. 2016 ; Vol. 139, No. 3. pp. 593-600.
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