Odorant identification and quality perception following methyl bromide-induced lesions of the olfactory epithelium

Steven Youngentob, James E. Schwob

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Using a 5-odorant identification confusion matrix task, the authors assessed the consequence of olfactory epithelial damage on odorant quality perception in the rat. After establishing prelesion identification performance, each rat's epithelium was subjected to 330 ppm methyl bromide gas for 6 hr. Comparison of prelesion and 3-day postlesion performance demonstrated a significant decrease in identification as a consequence of 95%-98% epithelial destruction. Further, there was a differential effect of lesion on the ability of different animals to identify the different individual odorants. Evaluation of the anatomical state of the epithelium relative to performance on the identification task demonstrated a significant relationship between the extent and location of anatomical sparing and changes in individual odorant identifications. Assessment of pre- and postlesion quality perception for the individual rats demonstrated a highly significant shift in quality perception that was independent of any decrease in performance. These results provide strong support for the proposition that the regional variations in mucosal sensitivities within and across olfactory receptor gene expression zones are fundamentally important for the encoding of odorant quality. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Original languageEnglish (US)
Pages (from-to)1346-1355
Number of pages10
JournalBehavioral Neuroscience
Volume120
Issue number6
DOIs
StatePublished - Dec 1 2006

Fingerprint

methyl bromide
Olfactory Mucosa
Epithelium
Odorant Receptors
Confusion
Aptitude
Gases
Odorants
Gene Expression

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Odorant identification and quality perception following methyl bromide-induced lesions of the olfactory epithelium. / Youngentob, Steven; Schwob, James E.

In: Behavioral Neuroscience, Vol. 120, No. 6, 01.12.2006, p. 1346-1355.

Research output: Contribution to journalArticle

@article{66eaebf1aa6e4de79ceb1a15adb1772b,
title = "Odorant identification and quality perception following methyl bromide-induced lesions of the olfactory epithelium",
abstract = "Using a 5-odorant identification confusion matrix task, the authors assessed the consequence of olfactory epithelial damage on odorant quality perception in the rat. After establishing prelesion identification performance, each rat's epithelium was subjected to 330 ppm methyl bromide gas for 6 hr. Comparison of prelesion and 3-day postlesion performance demonstrated a significant decrease in identification as a consequence of 95{\%}-98{\%} epithelial destruction. Further, there was a differential effect of lesion on the ability of different animals to identify the different individual odorants. Evaluation of the anatomical state of the epithelium relative to performance on the identification task demonstrated a significant relationship between the extent and location of anatomical sparing and changes in individual odorant identifications. Assessment of pre- and postlesion quality perception for the individual rats demonstrated a highly significant shift in quality perception that was independent of any decrease in performance. These results provide strong support for the proposition that the regional variations in mucosal sensitivities within and across olfactory receptor gene expression zones are fundamentally important for the encoding of odorant quality. (PsycINFO Database Record (c) 2006 APA, all rights reserved).",
author = "Steven Youngentob and Schwob, {James E.}",
year = "2006",
month = "12",
day = "1",
doi = "10.1037/0735-7044.120.6.1346",
language = "English (US)",
volume = "120",
pages = "1346--1355",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "6",

}

TY - JOUR

T1 - Odorant identification and quality perception following methyl bromide-induced lesions of the olfactory epithelium

AU - Youngentob, Steven

AU - Schwob, James E.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Using a 5-odorant identification confusion matrix task, the authors assessed the consequence of olfactory epithelial damage on odorant quality perception in the rat. After establishing prelesion identification performance, each rat's epithelium was subjected to 330 ppm methyl bromide gas for 6 hr. Comparison of prelesion and 3-day postlesion performance demonstrated a significant decrease in identification as a consequence of 95%-98% epithelial destruction. Further, there was a differential effect of lesion on the ability of different animals to identify the different individual odorants. Evaluation of the anatomical state of the epithelium relative to performance on the identification task demonstrated a significant relationship between the extent and location of anatomical sparing and changes in individual odorant identifications. Assessment of pre- and postlesion quality perception for the individual rats demonstrated a highly significant shift in quality perception that was independent of any decrease in performance. These results provide strong support for the proposition that the regional variations in mucosal sensitivities within and across olfactory receptor gene expression zones are fundamentally important for the encoding of odorant quality. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

AB - Using a 5-odorant identification confusion matrix task, the authors assessed the consequence of olfactory epithelial damage on odorant quality perception in the rat. After establishing prelesion identification performance, each rat's epithelium was subjected to 330 ppm methyl bromide gas for 6 hr. Comparison of prelesion and 3-day postlesion performance demonstrated a significant decrease in identification as a consequence of 95%-98% epithelial destruction. Further, there was a differential effect of lesion on the ability of different animals to identify the different individual odorants. Evaluation of the anatomical state of the epithelium relative to performance on the identification task demonstrated a significant relationship between the extent and location of anatomical sparing and changes in individual odorant identifications. Assessment of pre- and postlesion quality perception for the individual rats demonstrated a highly significant shift in quality perception that was independent of any decrease in performance. These results provide strong support for the proposition that the regional variations in mucosal sensitivities within and across olfactory receptor gene expression zones are fundamentally important for the encoding of odorant quality. (PsycINFO Database Record (c) 2006 APA, all rights reserved).

UR - http://www.scopus.com/inward/record.url?scp=33846108438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846108438&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.120.6.1346

DO - 10.1037/0735-7044.120.6.1346

M3 - Article

VL - 120

SP - 1346

EP - 1355

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 6

ER -