Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation

M. Cameron Ogg, Jordan M. Ross, Mounir Bendahmane, Max Fletcher

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Habituation and dishabituation modulate the neural resources and behavioral significance allocated to incoming stimuli across the sensory systems. We characterize these processes in the mouse olfactory bulb (OB) and uncover a role for OB acetylcholine (ACh) in physiological and behavioral olfactory dishabituation. We use calcium imaging in both awake and anesthetized mice to determine the time course and magnitude of OB glomerular habituation during a prolonged odor presentation. In addition, we develop a novel behavioral investigation paradigm to determine how prolonged odor input affects odor salience. We find that manipulating OB ACh release during prolonged odor presentations using electrical or optogenetic stimulation rapidly modulates habituated glomerular odor responses and odor salience, causing mice to suddenly investigate a previously ignored odor. To demonstrate the ethological validity of this effect, we show that changing the visual context can lead to dishabituation of odor investigation behavior, which is blocked by cholinergic antagonists in the OB.

Original languageEnglish (US)
Article number1868
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

acetylcholine
odors
bulbs
Olfactory Bulb
Odors
Acetylcholine
mice
cholinergics
Optogenetics
Odorants
Cholinergic Antagonists
stimulation
stimuli
calcium
resources
Calcium
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation. / Ogg, M. Cameron; Ross, Jordan M.; Bendahmane, Mounir; Fletcher, Max.

In: Nature Communications, Vol. 9, No. 1, 1868, 01.12.2018.

Research output: Contribution to journalArticle

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