Oligomerization of the heptahelical G protein coupling receptors

A case for association using transmembrane helices

M. S. Parker, R. Sah, Edwards Park, T. Sweatman, A. Balasubramaniam, F. R. Sallee, Steven Leonard Parker

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The heptahelical G protein coupling receptors oligomerize extensively via transmembrane domains, in association with heterotrimeric G proteins. This provides higher affinity for agonists, conformational stability necessary for signal transduction, and protection from intracellular proteinases. The oligomerization is relevant to organismic pathophysiology and could be targeted by natural or modified agonists.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalMini-Reviews in Medicinal Chemistry
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2009

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Heterotrimeric GTP-Binding Proteins
GTP-Binding Proteins
Signal Transduction
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Oligomerization of the heptahelical G protein coupling receptors : A case for association using transmembrane helices. / Parker, M. S.; Sah, R.; Park, Edwards; Sweatman, T.; Balasubramaniam, A.; Sallee, F. R.; Parker, Steven Leonard.

In: Mini-Reviews in Medicinal Chemistry, Vol. 9, No. 3, 01.01.2009, p. 329-339.

Research output: Contribution to journalArticle

Parker, M. S. ; Sah, R. ; Park, Edwards ; Sweatman, T. ; Balasubramaniam, A. ; Sallee, F. R. ; Parker, Steven Leonard. / Oligomerization of the heptahelical G protein coupling receptors : A case for association using transmembrane helices. In: Mini-Reviews in Medicinal Chemistry. 2009 ; Vol. 9, No. 3. pp. 329-339.
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