OMP gene deletion results in an alteration in odorant quality perception

Steven L. Youngento, Frank L. Margolis, Lisa Youngentob

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

To test the hypothesis that odorant quality perception is altered in olfactory marker protein (OMP)-null mice, we trained and tested adult OMP-null and control mice, using a 5-odorant identification confusion matrix task (animal odorant confusion matrix [AOCM]). On average, control and null mice performed the task at equivalent levels. The composite 5 × 5 response matrix from 40 testing sessions for each subject (both OMP-null and control) was compared with that of every other subject, yielding a dissimilarity matrix of AOCM responses. A multidimensional scaling (MDS) analysis of the dissimilarity data yielded a 4-dimensional solution, with each mouse occupying a point in MDS animal space. Statistical analysis demonstrated significant effects of genotype in determining the location of a mouse in the MDS space. These data suggest, therefore, that compared with that of controls, odorant quality perception is altered in the OMP-null mouse.

Original languageEnglish (US)
Pages (from-to)626-631
Number of pages6
JournalBehavioral Neuroscience
Volume115
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Olfactory Marker Protein
Gene Deletion
Confusion
Quality Control
Genotype
Odorants

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

OMP gene deletion results in an alteration in odorant quality perception. / Youngento, Steven L.; Margolis, Frank L.; Youngentob, Lisa.

In: Behavioral Neuroscience, Vol. 115, No. 3, 2001, p. 626-631.

Research output: Contribution to journalArticle

Youngento, Steven L. ; Margolis, Frank L. ; Youngentob, Lisa. / OMP gene deletion results in an alteration in odorant quality perception. In: Behavioral Neuroscience. 2001 ; Vol. 115, No. 3. pp. 626-631.
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