One more disguise in the stealth behavior of Streptococcus pyogenes

Vincent A. Fischetti, James Dale

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Abstract

The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining human joints. It has also acquired the capacity to enter eukaryotic cells to avoid the onslaught of the host’s immune defenses, as well as drugs. From this intracellular vantage point, it may remain dormant from days to weeks, only to cause disease again at a later time, perhaps causing a relapse in a drug-treated patient. We now learn that it is able to enter macrophages as well, enabling the Streptococcus to use this "Trojan horse" approach to be transported to distant sites in the body.

Original languageEnglish (US)
Article numbere00661-16
JournalmBio
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2016

Fingerprint

Streptococcus pyogenes
Hyaluronic Acid
Bacteria
Aptitude
Eukaryotic Cells
Streptococcus
Pharmaceutical Preparations
Capsules
Joints
Macrophages
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Virology

Cite this

One more disguise in the stealth behavior of Streptococcus pyogenes. / Fischetti, Vincent A.; Dale, James.

In: mBio, Vol. 7, No. 3, e00661-16, 01.01.2016.

Research output: Contribution to journalComment/debate

@article{3bdcb3a8019b4b4b93f9b34f3bc34d7a,
title = "One more disguise in the stealth behavior of Streptococcus pyogenes",
abstract = "The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining human joints. It has also acquired the capacity to enter eukaryotic cells to avoid the onslaught of the host’s immune defenses, as well as drugs. From this intracellular vantage point, it may remain dormant from days to weeks, only to cause disease again at a later time, perhaps causing a relapse in a drug-treated patient. We now learn that it is able to enter macrophages as well, enabling the Streptococcus to use this {"}Trojan horse{"} approach to be transported to distant sites in the body.",
author = "Fischetti, {Vincent A.} and James Dale",
year = "2016",
month = "1",
day = "1",
doi = "10.1128/mBio.00661-16",
language = "English (US)",
volume = "7",
journal = "mBio",
issn = "2161-2129",
publisher = "American Society for Microbiology",
number = "3",

}

TY - JOUR

T1 - One more disguise in the stealth behavior of Streptococcus pyogenes

AU - Fischetti, Vincent A.

AU - Dale, James

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining human joints. It has also acquired the capacity to enter eukaryotic cells to avoid the onslaught of the host’s immune defenses, as well as drugs. From this intracellular vantage point, it may remain dormant from days to weeks, only to cause disease again at a later time, perhaps causing a relapse in a drug-treated patient. We now learn that it is able to enter macrophages as well, enabling the Streptococcus to use this "Trojan horse" approach to be transported to distant sites in the body.

AB - The ability to hide in the animal kingdom is essential for survival; the same is true for bacteria. Streptococcus pyogenes is considered one of the more successful stealth bacteria in its production of a hyaluronic acid capsule that is chemically identical to the hyaluronic acid lining human joints. It has also acquired the capacity to enter eukaryotic cells to avoid the onslaught of the host’s immune defenses, as well as drugs. From this intracellular vantage point, it may remain dormant from days to weeks, only to cause disease again at a later time, perhaps causing a relapse in a drug-treated patient. We now learn that it is able to enter macrophages as well, enabling the Streptococcus to use this "Trojan horse" approach to be transported to distant sites in the body.

UR - http://www.scopus.com/inward/record.url?scp=84978993793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978993793&partnerID=8YFLogxK

U2 - 10.1128/mBio.00661-16

DO - 10.1128/mBio.00661-16

M3 - Comment/debate

VL - 7

JO - mBio

JF - mBio

SN - 2161-2129

IS - 3

M1 - e00661-16

ER -