One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the look AHEAD study

Lucy F. Faulconbridge, Thomas A. Wadden, Richard R. Rubin, Rena R. Wing, Michael P. Walkup, Anthony N. Fabricatore, Mathilda Coday, Brent Van Dorsten, David L. Mount, Linda J. Ewing

Research output: Contribution to journalArticle

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Abstract

Depressed individuals are frequently excluded from weight loss trials because of fears that weight reduction may precipitate mood disorders, as well as concerns that depressed participants will not lose weight satisfactorily. The present study examined participants in the Look AHEAD study to determine whether moderate weight loss would be associated with incident symptoms of depression and suicidal ideation, and whether symptoms of depression at baseline would limit weight loss at 1 year. Overweight/obese adults with type 2 diabetes (n = 5,145) were randomly assigned to an Intensive Lifestyle Intervention (ILI) or a usual care group, Diabetes Support and Education (DSE). Of these, 5,129 participants completed the Beck Depression Inventory (BDI) and had their weight measured at baseline and 1 year. Potentially significant symptoms of depression were defined by a BDI score 10. Participants in ILI lost 8.6±6.9% of initial weight at 1 year, compared to 0.7±4.8% for DSE (P<0.001, effect size = 1.33), and had a reduction of 1.4±4.7 points on the BDI, compared to 0.4±4.5 for DSE (P<0.001, effect size = 0.23). At 1 year, the incidence of potentially significant symptoms of depression was significantly lower in the ILI than DSE group (6.3% vs. 9.6%) (relative risk (RR) = 0.66, 95% confidence interval (CI) = 0.5, 0.8; P<0.001). In the ILI group, participants with and without symptoms of depression lost 7.8±6.7% and 8.7±6.7% and 8.76.9%, respectively, a difference not considered clinically meaningful. Intentional weight loss was not associated with the precipitation of symptoms of depression, but instead appeared to protect against this occurrence. Mild (or greater) symptoms of depression at baseline did not prevent overweight/obese individuals with type 2 diabetes from achieving significant weight loss.

Original languageEnglish (US)
Pages (from-to)783-793
Number of pages11
JournalObesity
Volume20
Issue number4
DOIs
StatePublished - Apr 1 2012

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Type 2 Diabetes Mellitus
Depression
Weights and Measures
Weight Loss
Life Style
Education
Equipment and Supplies
Suicidal Ideation
Mood Disorders
Fear
Confidence Intervals
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Faulconbridge, L. F., Wadden, T. A., Rubin, R. R., Wing, R. R., Walkup, M. P., Fabricatore, A. N., ... Ewing, L. J. (2012). One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the look AHEAD study. Obesity, 20(4), 783-793. https://doi.org/10.1038/oby.2011.315

One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the look AHEAD study. / Faulconbridge, Lucy F.; Wadden, Thomas A.; Rubin, Richard R.; Wing, Rena R.; Walkup, Michael P.; Fabricatore, Anthony N.; Coday, Mathilda; Van Dorsten, Brent; Mount, David L.; Ewing, Linda J.

In: Obesity, Vol. 20, No. 4, 01.04.2012, p. 783-793.

Research output: Contribution to journalArticle

Faulconbridge, LF, Wadden, TA, Rubin, RR, Wing, RR, Walkup, MP, Fabricatore, AN, Coday, M, Van Dorsten, B, Mount, DL & Ewing, LJ 2012, 'One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the look AHEAD study', Obesity, vol. 20, no. 4, pp. 783-793. https://doi.org/10.1038/oby.2011.315
Faulconbridge, Lucy F. ; Wadden, Thomas A. ; Rubin, Richard R. ; Wing, Rena R. ; Walkup, Michael P. ; Fabricatore, Anthony N. ; Coday, Mathilda ; Van Dorsten, Brent ; Mount, David L. ; Ewing, Linda J. / One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the look AHEAD study. In: Obesity. 2012 ; Vol. 20, No. 4. pp. 783-793.
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